Enzyme Cleavable Linkers (Cleave Motif) [Reagents for ADC Preparation Research] — includes peptide linker motifs such as Val-Cit and its derivatives, along with Fmoc or Alloc protecting groups, designed to be specifically cleaved by protease enzymes. This category serves as the structural component connecting the payload and the carrier in molecular conjugation research.
Val-Cit-PAB-based linkers and their derivatives are used by bioorganic chemistry researchers in assembling antibody-drug conjugate (ADC) structures for research, where the peptide bond is designed to be cleaved by specific enzymes after internalization. Reagents such as acetylated galactosides are also used in alternative linker approaches based on sugar groups for studies of controlled payload release.
Example products in this collection: TCI V0155 159857-79-1 Val-Cit-PAB-OH, TCI F1114 863971-53-3 Fmoc-Val-Cit-PAB-PNP, TCI A3348 1608127-09-8 Alloc-Val-Cit-PAB-OH, TCI F1223 159858-22-7 Fmoc-Val-Cit-PAB-OH, TCI M3224 159857-80-4 MC-Val-Cit-PAB-OH, TCI F1249 870487-04-0 Fmoc-Cit-PAB-OH, TCI M3209 159857-81-5 Mc-Val-Cit-PABC-PNP, TCI F1405 77667-26-6 4-Formyl-2-nitrophenyl 2,3,4,6-Tetra-O-acetyl-beta-D-galactopyranoside.
Pay attention to the terminal protecting groups (Fmoc, Alloc, or Mc), which must match the conjugation synthesis strategy being used, as well as peptide purity for consistent coupling reaction results. All products are genuine Tokyo Chemical Industry (TCI) Japan products, with purity, packaging, and storage conditions listed on each item's page.
Other categories parallel under Antibody-Drug Conjugates (ADC) Preparation Research Reagents, often used together in one laboratory workflow:
Back to Antibody-Drug Conjugates (ADC) Preparation Research Reagents. For large-volume procurement, special packaging, or specific grades, contact the AMI Scientific team, the official TCI Japan distributor in Indonesia, for availability checks and lead time directly from Japan.
