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CAS 31277-98-2

Bis[1,2-bis(diphenylphosphino)ethane]palladium(0) TCI B3224

Bis[1,2-bis(diphenylphosphino)ethane]palladium(0) TCI B3224
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Bis[1,2-bis(diphenylphosphino)ethane]palladium(0), also known as Pd(dppe)2, is a transition metal complex consisting of a palladium atom in the zero oxidation state stabilized by two bidentate 1,2-bis(diphenylphosphino)ethane ligands. In the chemistry laboratory, this compound serves primarily as a homogeneous catalyst for a wide range of carbon-carbon bond-forming reactions, especially cross-coupling reactions such as Suzuki-Miyaura, Heck, and Sonogashira couplings. As a ready-to-use source of palladium(0), it allows researchers to initiate catalytic reactions without going through a complicated and time-consuming pre-reduction step, which is a significant practical advantage in routine synthesis work.

The main advantage of this compound lies in the stability of the palladium(0) complex, which is maintained by the strongly chelating diphosphine ligands, so the catalyst is not easily oxidized during weighing or storage. The bidentate dppe ligand forms a five-membered chelate ring with the metal center, producing a stable and well-defined coordination environment that supports consistent catalytic performance. This TCI product is packaged in tightly sealed glass bottles in 1 gram and 5 gram sizes, designed to meet the needs of organic synthesis from test-tube scale up to preparative scale, making it a practical and dependable choice for laboratory work.

In Indonesian laboratories, this compound is typically used as a catalyst in organic synthesis and pharmaceutical research settings where cross-coupling methodology is applied to build complex molecules. Researchers commonly employ it in small-scale screening experiments, method development, and preparative synthesis, where its ready-to-use nature saves valuable preparation time. Its stable, easy-to-handle form makes it suitable for academic research groups, analytical service laboratories, and industrial R&D facilities across Indonesia that conduct palladium-catalyzed transformations on a routine basis.

  • Suzuki-Miyaura cross-coupling: as a pre-formed palladium(0) source, Pd(dppe)2 enters the catalytic cycle directly, enabling efficient coupling of organoboron reagents with aryl halides without requiring any prior activation or reduction step.
  • Heck reaction: the stable palladium(0) center readily participates in oxidative addition and migratory insertion, making this complex a convenient catalyst for the vinylation of aryl and alkenyl halides in organic synthesis.
  • Sonogashira coupling: this complex provides active palladium(0) for the coupling of terminal alkynes with aryl or vinyl halides, typically used together with a copper co-catalyst in a standard procedure.
  • Catalyst screening and reaction optimization: as a well-defined single-component catalyst, it is ideal for evaluating reaction conditions and ligand effects during method development in organic chemistry laboratories.
  • Preparative-scale organic synthesis: its ready-to-use form and reliable activity allow straightforward scale-up from test-tube reactions to gram-scale preparative batches without complex catalyst pre-activation procedures.

Brand TCI
CAS number 31277-98-2
Molecular formula
Purity
Category Chemistry > Catalysis and Inorganic Chemistry > Transition Elements
Pack sizes 1 g and 5 g glass bottles with tight closures
Physical form supplied as a stable palladium(0) complex in sealed glass bottles
Storage
  • Product code: B3224

Store this product in its original tightly sealed glass bottle, kept in a cool, dry place away from direct sunlight and sources of heat. Although the palladium(0) complex is stabilized by its chelating diphosphine ligands and resists oxidation during normal handling, prolonged exposure to air and moisture should still be avoided to preserve catalytic activity. When weighing, use clean, dry spatulas and close the container immediately after use. Wear appropriate personal protective equipment such as laboratory gloves and safety glasses, and follow standard chemical hygiene practices in the laboratory. Keep the product away from incompatible materials, open flames, and food items, and ensure the container is clearly labeled with the product name and CAS number at all times.