Bisindolylmaleimide IV (TCI B6068) is a chemical compound widely used in life science research, particularly in the study of cell signaling and neuroscience. As a potent inhibitor of protein kinase C (PKC), this compound plays a critical role in cellular signal transduction pathways. It is commonly utilized in laboratory settings to modulate PKC activity, enabling researchers to investigate its impact on various biological processes such as cell differentiation, apoptosis, and immune responses. Its importance lies in its ability to provide insights into the molecular mechanisms underlying these complex biological functions.
The compound is valued for its chemical stability and high solubility in organic solvents like DMSO, making it easy to dissolve and incorporate into experimental protocols. Its strong affinity for its target enzyme ensures high efficacy in inhibiting PKC, which is essential for studies requiring precise modulation of signaling pathways. These properties make it a reliable and effective tool for researchers aiming to explore the role of PKC in both normal and pathological conditions.
In Indonesian laboratories, Bisindolylmaleimide IV is a key reagent in biomedical, pharmacological, and neurobiological research. Its use supports the development of new therapeutic strategies and the understanding of disease mechanisms. Due to its reliability and effectiveness, it is a preferred choice for scientists working in these fields.
- Cell Signaling Studies: This compound is ideal for investigating the role of PKC in intracellular signaling pathways, allowing researchers to analyze how its inhibition affects cellular responses.
- Neurobiological Research: It is used to study the impact of PKC inhibition on neuronal function, helping to uncover mechanisms related to neurodegenerative diseases and synaptic plasticity.
- Apoptosis and Cell Differentiation: Its ability to modulate PKC activity makes it suitable for experiments examining the role of this enzyme in programmed cell death and developmental processes.
- Immunological Investigations: Researchers use it to study how PKC inhibition influences immune cell activation and response, contributing to the understanding of immune-related disorders.
- Drug Development: It serves as a tool in the development of pharmaceutical compounds targeting PKC, aiding in the design of potential therapeutic agents.
| Brand | TCI |
|---|---|
| CAS number | 119139-23-0 |
| Molecular formula | — |
| Purity | — |
| Category | Life Science > Cell Biology > Cell Signaling and Neuroscience |
| Pack sizes | — |
| Physical form | — |
| Storage | Store in a cool, dry place away from light |
Bisindolylmaleimide IV should be stored in a cool, dry place, away from direct light to maintain its chemical stability. It is recommended to use airtight containers to prevent moisture absorption, which could affect its potency. Due to its potential reactivity, it should be handled with appropriate personal protective equipment, such as gloves and safety goggles. In laboratory settings, it is important to ensure proper ventilation when working with this compound. It should not be disposed of in drains or landfills without following local regulations for chemical waste. Proper labeling and storage are essential to ensure safety and maintain the integrity of the compound for research use.
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