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Description
3-(Bromomethyl)oxetane (CAS 1374014-30-8) combines a strained four-membered oxetane ring with a reactive bromomethyl handle, making it a versatile heterocyclic building block. It is used to alkylate amines, alkoxides, thiolates, and carbanions, introducing an oxetane motif that medicinal chemists often employ as a bioisostere for gem-dimethyl or carbonyl groups to tune solubility and metabolic stability. As a reactive alkylating agent it should be handled in a fume hood with gloves and eye protection, kept away from strong acids that can open the oxetane ring, and stored cool, dry, and tightly closed. AMI Scientific offers a 200 mg pack size for synthetic and drug discovery laboratories.
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