![TCI B6619 22287-28-1 Bicyclo[1.1.1]pentane-1-carboxylic Acid](http://amiscientific.com/cdn/shop/files/TCI2510B6619_2e3a92f0-bc4a-4b92-a34b-3fb2dab9cc6f.jpg?v=1792631767&width=1946)
![Bicyclo[1.1.1]pentane-1-carboxylic Acid (CAS 22287-28-1) - TCI B6619 - AMI Scientific](http://amiscientific.com/cdn/shop/files/TCI2510B6619.jpg?v=1767094032&width=1946)
![TCI B6619 22287-28-1 Bicyclo[1.1.1]pentane-1-carboxylic Acid](http://amiscientific.com/cdn/shop/files/TCI2510B6619_2e3a92f0-bc4a-4b92-a34b-3fb2dab9cc6f.jpg?v=1792631767&width=1445)
![Bicyclo[1.1.1]pentane-1-carboxylic Acid (CAS 22287-28-1) - TCI B6619 - AMI Scientific](http://amiscientific.com/cdn/shop/files/TCI2510B6619.jpg?v=1767094032&width=1445)
TCI B6619 is bicyclo[1.1.1]pentane-1-carboxylic acid, a monofunctional derivative of the widely studied BCP cage. The bridgehead-to-bridgehead axis of bicyclo[1.1.1]pentane closely mimics the linear geometry of para-substituted benzene rings, making it a favoured aromatic bioisostere. Replacing arenes with BCP units is frequently associated with improved aqueous solubility, reduced lipophilicity, and enhanced metabolic stability. AMI Scientific supplies this TCI building block in a 100 mg pack size for drug discovery and organic synthesis laboratories.
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TCI brochures (PDF)
- Bicycloalkane Building Blocks ― Benzene Bioisosteres ― 2025-04-01 · p. 1
Related TCI products
- TCI M3710 65862-01-3 3-Methylbicyclo[1.1.1]pentane-1-carboxylic Acid
- TCI M3149 83249-10-9 3-(Methoxycarbonyl)bicyclo[111]pentane-1-carboxylic Acid
- TCI D6351 115913-32-1 Dimethyl Bicyclo[1.1.1]pentane-1,3-dicarboxylate
- TCI D6184 303752-38-7 3-[(tert-Butoxycarbonyl)amino]bicyclo[1.1.1]pentane-1-carboxylic Acid
- TCI B6522 56842-95-6 Bicyclo[1.1.1]pentane-1,3-dicarboxylic Acid
- TCI M3703 141046-52-8 4-(Methoxycarbonyl)bicyclo[2.1.1]hexane-1-carboxylic Acid
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References cited in the TCI brochure
- Murugaiah A. M. Subbaiah. Bioisosteres of the Phenyl Ring: Recent Strategic Applications in Lead Optimization and Drug Design Journal of Medicinal Chemistry, 2021. doi:10.1021/acs.jmedchem.1c01215
Product Categories
- Building BlocksNon-Heterocyclic Building BlocksCarbonyl Compounds [Non-Heterocyclic Building Blocks]
- Building BlocksSpecialized Building Blocks for Drug DiscoveryBicyclo[1.1.1]pentane Building Blocks
- Pharmaceutical Development and Drug Discovery Research ReagentsSpecialized Building Blocks for Drug DiscoveryBicyclo[1.1.1]pentane Building Blocks
Produk Terkait
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3-Methylbicyclo[1.1.1]pentane-1-carboxylicAcid TCI M3710
Regular price Rp 6.811.350,00Regular priceRp 4.778.550,00Sale price Rp 6.811.350,00 -
3-(Methoxycarbonyl)bicyclo[111]pentane-1-carboxylicAcid TCI M3149
Regular price From Rp 955.500,00Regular priceRp 667.800,00Sale price From Rp 955.500,00 -
DimethylBicyclo[1.1.1]pentane-1,3-dicarboxylate TCI D6351
Regular price Rp 3.260.250,00Regular priceRp 2.279.550,00Sale price Rp 3.260.250,00 -
3-[(tert-Butoxycarbonyl)amino]bicyclo[1.1.1]pentane-1-carboxylicAcid TCI D6184
Regular price From Rp 2.227.050,00Regular priceRp 1.572.900,00Sale price From Rp 2.227.050,00 -
Bicyclo[1.1.1]pentane-1,3-dicarboxylicAcid TCI B6522
Regular price Rp 4.797.450,00Regular priceRp 3.354.750,00Sale price Rp 4.797.450,00 -
4-(Methoxycarbonyl)bicyclo[2.1.1]hexane-1-carboxylicAcid TCI M3703
Regular price Rp 5.352.900,00Regular priceRp 3.743.250,00Sale price Rp 5.352.900,00 -
5-(Methoxycarbonyl)bicyclo[3.1.1]heptane-1-carboxylicAcid TCI M3701
Regular price Rp 5.247.900,00Regular priceRp 3.669.750,00Sale price Rp 5.247.900,00 -
4-[(tert-Butoxycarbonyl)amino]bicyclo[2.1.1]hexane-1-carboxylicAcid TCI B6609
Regular price Rp 5.062.050,00Regular priceRp 3.555.300,00Sale price Rp 5.062.050,00
![TCI M3710 65862-01-3 3-Methylbicyclo[1.1.1]pentane-1-carboxylic Acid](http://amiscientific.com/cdn/shop/files/TCI2510M3710_10484897-db58-4d7c-a9b9-608013155131.jpg?v=1792649949&width=533)
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![TCI M3149 83249-10-9 3-(Methoxycarbonyl)bicyclo[111]pentane-1-carboxylic Acid](http://amiscientific.com/cdn/shop/files/TCI2510M3149_34d68d32-391c-4000-b00c-ddb6f7a9df59.jpg?v=1792649512&width=533)
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![TCI D6351 115913-32-1 Dimethyl Bicyclo[1.1.1]pentane-1,3-dicarboxylate](http://amiscientific.com/cdn/shop/files/TCI2510D6351_f5e04f49-f07b-4fd4-b6cc-11472f52efd2.jpg?v=1792640502&width=533)
![Dimethyl Bicyclo[1.1.1]pentane-1,3-dicarboxylate (CAS 115913-32-1) - TCI D6351 - AMI Scientific](http://amiscientific.com/cdn/shop/files/TCI2510D6351.jpg?v=1767110078&width=533)
![TCI D6184 303752-38-7 3-[(tert-Butoxycarbonyl)amino]bicyclo[1.1.1]pentane-1-carboxylic Acid](http://amiscientific.com/cdn/shop/files/TCI2510D6184_5ec8c9c3-9502-47b6-9263-5d709a4dafda.jpg?v=1792640434&width=533)
![3-[(tert-Butoxycarbonyl)amino]bicyclo[1.1.1]pentane-1-carboxylic Acid (CAS 303752-38-7) - TCI D6184 - AMI Scientific](http://amiscientific.com/cdn/shop/files/TCI2510D6184.jpg?v=1767109862&width=533)
![TCI B6522 56842-95-6 Bicyclo[1.1.1]pentane-1,3-dicarboxylic Acid](http://amiscientific.com/cdn/shop/files/TCI2510B6522_857dfac2-d34d-4819-ad0a-02a2da3264a6.jpg?v=1792631616&width=533)
![Bicyclo[1.1.1]pentane-1,3-dicarboxylic Acid (CAS 56842-95-6) - TCI B6522 - AMI Scientific](http://amiscientific.com/cdn/shop/files/TCI2510B6522.jpg?v=1767093799&width=533)
![TCI M3703 141046-52-8 4-(Methoxycarbonyl)bicyclo[2.1.1]hexane-1-carboxylic Acid](http://amiscientific.com/cdn/shop/files/TCI2510M3703_23a5d08e-b43f-4f06-9bf1-3ebbbe36afa3.jpg?v=1792649943&width=533)
![141046-52-8 4-(Methoxycarbonyl)bicyclo[2.1.1]hexane-1-carboxylic Acid - AMI Scientific](http://amiscientific.com/cdn/shop/files/TCI2510M3703.jpg?v=1767128696&width=533)
![TCI M3701 110371-28-3 5-(Methoxycarbonyl)bicyclo[3.1.1]heptane-1-carboxylic Acid](http://amiscientific.com/cdn/shop/files/TCI2510M3701_b49b0d6a-b274-418a-b1a3-4f2c9656ca54.jpg?v=1792649941&width=533)
![110371-28-3 5-(Methoxycarbonyl)bicyclo[3.1.1]heptane-1-carboxylic Acid - AMI Scientific](http://amiscientific.com/cdn/shop/files/TCI2510M3701.jpg?v=1767128692&width=533)
![TCI B6609 1050886-56-0 4-[(tert-Butoxycarbonyl)amino]bicyclo[2.1.1]hexane-1-carboxylic Acid](http://amiscientific.com/cdn/shop/files/TCI2510B6609_bb2396e9-004b-4505-b1af-0161c6a47654.jpg?v=1792631755&width=533)
![4-[(tert-Butoxycarbonyl)amino]bicyclo[2.1.1]hexane-1-carboxylic Acid (CAS 1050886-56-0) - TCI B6609 - AMI Scientific](http://amiscientific.com/cdn/shop/files/TCI2510B6609.jpg?v=1767094020&width=533)