Benzoyl Chloride (DualSeal) from TCI is an aromatic acyl chloride and one of the classic reagents in organic synthesis. It is mainly used as a benzoylating agent, attaching a benzoyl group to alcohols, phenols, amines, and other nucleophiles. In the laboratory, benzoyl chloride is used to prepare esters and amides, to protect functional groups during multi-step synthesis, and to make derivatives that are easier to analyse. TCI's DualSeal packaging is designed to keep this moisture-sensitive reagent in good condition, so it stays reliable from the first use to the last.
Benzoyl chloride reacts readily with nucleophiles. Acylation reactions usually proceed quickly under fairly simple conditions, for example with an amine base or under Schotten–Baumann conditions. Its main drawback is that water or humid air easily hydrolyses it to benzoic acid and hydrogen chloride, so its quality can drop if the container is opened often. The DualSeal packaging addresses this. Its layered closure helps keep humid air out, so the reagent keeps its quality even when it is dispensed many times. The 25 mL pack size is convenient for gradual use, so a small amount can be taken for each reaction without exposing a large stock.
Indonesia's tropical climate keeps ambient humidity high in many laboratories, so moisture-sensitive reagents such as benzoyl chloride need particular care. University organic chemistry laboratories, research institutes, and industrial R&D facilities use this reagent for teaching syntheses, preparing intermediates, and making derivatives for analysis. The DualSeal format helps these laboratories keep the reagent reliable between sessions, even where the reagent is shared among several users or opened often over a semester or a project.
Related TCI products
- TCI U0174 543-20-4 Succinyl Chloride (DualSeal)
- TCI T2341 36823-88-8 4-(Trifluoromethoxy)benzoyl Chloride
- TCI T2334 86270-03-3 3-(Trifluoromethoxy)benzoyl Chloride
- TCI T1335 2251-65-2 3-(Trifluoromethyl)benzoyl Chloride
- TCI T1301 329-15-7 4-(Trifluoromethyl)benzoyl Chloride
- TCI T1280 312-94-7 2-(Trifluoromethyl)benzoyl Chloride
- Benzoylation of alcohols and phenols: this reagent reacts quickly with hydroxyl groups and gives benzoate esters under simple conditions with an amine base.
- Amide synthesis from amines: its high reactivity toward nitrogen nucleophiles makes it well suited to preparing benzamides, including under classic Schotten–Baumann conditions.
- Protecting-group strategies in multi-step synthesis: the benzoyl group can be attached to protect alcohols or amines during later reaction steps, and the moisture-protective DualSeal pack keeps the reagent consistent.
- Derivatisation for analysis: converting compounds into benzoyl derivatives can make them easier to analyse, and the reagent's fast acylation suits routine sample preparation.
- Teaching and research organic chemistry laboratories: benzoylation is a classic textbook reaction, and the 25 mL DualSeal pack lets small amounts be dispensed repeatedly without degrading the remaining reagent.
| Brand | TCI |
|---|---|
| CAS number | 98-88-4 |
| Molecular formula | — |
| Purity | — |
| Category | TCI |
| Pack sizes | 25 mL |
| Physical form | — |
| Storage | moisture-sensitive; hydrolyses to benzoic acid and hydrogen chloride on contact with water or humid air. Keep tightly closed. |
- Product code: B6723 (DualSeal packaging)
Store benzoyl chloride in its original DualSeal container, tightly closed, in a cool, dry, well-ventilated area away from water, humid air, alcohols, amines, and bases. Close the container promptly after each use to limit moisture entry, which matters most in humid tropical laboratories. Dispense the reagent with clean, dry glassware or syringes. Handle it in a fume hood, because hydrolysis releases hydrogen chloride and the vapours irritate the eyes and respiratory tract. Wear chemical-resistant gloves, safety goggles, and a lab coat. Consult the supplier's Safety Data Sheet before use and for waste disposal.
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