TCI B6853 tert-Butyl (trans-3-Aminocyclobutyl)carbamate is a mono-Boc-protected cyclobutane diamine with a defined trans relationship between its two nitrogen substituents. The single free amine can be acylated, alkylated, or reductively aminated while the Boc group masks the second nitrogen for later use. Its rigid, sp3-rich cyclobutane core is valued in medicinal chemistry as an alternative to flat aromatic rings and flexible chains. AMI Scientific supplies this TCI building block in a 500 mg pack for exploratory and analogue synthesis.
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- Caprio et al. (2001). tert-Butyl methoxy(2-propynyl)carbamate. Molecules doi:10.3390/m200
- Chmovzh et al. (2021). tert-Butyl Bis(4′-(Hexyloxy)-[1,1′-biphenyl]-4-yl)carbamate. Molbank doi:10.3390/m1247
- (2009). MILD AND EFFICIENT ONE-POT CURTIUS REARRANGEMENT: PREPARATION OF N-tert-BUTYL ADAMANTANYL-1-YL-CARBAMATE. Organic Syntheses doi:10.15227/orgsyn.086.0113
References were compiled automatically from Crossref and every DOI was verified to exist. AMI Scientific is not affiliated with the authors or the publishers.
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