TCI C0252 2-Chloro-4'-phenylacetophenone is an α-chloroketone bearing a biphenyl unit, in which the chlorine adjacent to the carbonyl group provides strong electrophilic reactivity. It is commonly used to build thiazole and imidazole rings through reaction with thiourea or amides, and also serves as a selective alkylating reagent toward amines, thiols, and carboxylates. Phenacyl chlorides are typically strong irritants, so handle the material in a fume hood with gloves and eye protection. Store the solid cool, dry, and protected from light, and follow the official TCI Safety Data Sheet at all times.
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