TCI C0981 Cyclopropylamine (CAS 765-30-0) is a volatile primary amine bearing a strained three-membered ring, supplied in 5 mL and 25 mL bottles. Its nucleophilic amine reacts readily to form amides, sulfonamides, ureas, carbamates, and aromatic substitution products. The N-cyclopropyl motif is a well-known feature in medicinal chemistry, notably within quinolone antibacterial scaffolds. The material is highly flammable and corrosive, so handle it in a fume hood away from ignition sources and keep it tightly closed under cool storage.
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- Davidson et al. (1991). Inhibition by cyclopropylamine of the quinoprotein methylamine dehydrogenase is mechanism-based and causes covalent crosslinking of .alpha. and .beta. subunits. Biochemistry doi:10.1021/bi00221a027
- Manakhov et al. (2014). Cyclopropylamine plasma polymers deposited onto quartz crystal microbalance for biosensing application. physica status solidi (a) doi:10.1002/pssa.201431399
- Mao et al. (2014). ChemInform Abstract: Asymmetric Synthesis of Cyclopropylamine Derivatives. ChemInform doi:10.1002/chin.201439269
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