TCI C0995 3-Chloropropiophenone (CAS 936-59-4) is a versatile β-chloroketone building block combining an aryl ketone with a readily displaced beta chlorine atom. Chemists commonly use it to prepare β-aminoketones by substitution with amines, or to generate a reactive Michael acceptor in situ through HCl elimination. Selective carbonyl reduction also provides chlorohydrin intermediates that support downstream and asymmetric synthesis work. AMI Scientific supplies this TCI reagent in a 25 g research pack; keep it tightly closed in a cool, dry place away from moisture and strong bases.
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- Chen et al. (2014). 2-Bromo-3′-chloropropiophenone is a genotoxic impurity. Toxicology Letters doi:10.1016/j.toxlet.2014.06.682
- Sonneck et al. (2025). 3-Chloropropiophenone. IUCrData doi:10.1107/s2414314625003499
- Usui et al. (1998). Stereoselectivities in AgBF4-catalyzed and photoinduced phenyl-rearrangement of 2-chloropropiophenone. Tetrahedron Letters doi:10.1016/s0040-4039(98)02284-9
References were compiled automatically from Crossref and every DOI was verified to exist. AMI Scientific is not affiliated with the authors or the publishers.
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