2'-Chloroacetophenone from TCI, product code C1084, is an acetophenone derivative with a chlorine atom at the ortho position of the benzene ring. The prime (2') in the name shows that the chlorine is attached to the aromatic ring, not to the methyl group. This sets it apart from other compounds with similar names. In synthetic laboratories it serves as a non-heterocyclic building block because it has two reactive sites, a ketone group and an aromatic halogen. Chemists can modify either site to build more complex molecules.
Chemists choose this compound because its functional groups are versatile. The carbonyl group can be reduced to an alcohol, including by asymmetric reduction to give chiral alcohols. It can also be condensed with amines or other carbonyl compounds and converted into a range of heterocycles. The ortho chlorine has its own steric and electronic effects and can take part in coupling reactions catalysed by transition metals. Having both handles in one small aromatic molecule lets researchers plan multi-step routes from a single starting material. For technical data such as purity, refer to the TCI certificate of analysis.
In Indonesia, 2'-Chloroacetophenone suits university organic chemistry laboratories and pharmaceutical research centres that need a dependable aromatic ketone for synthesis work. Research groups developing new compounds, student thesis projects on synthetic methodology, and teams preparing intermediates for structure–activity studies can all use it as a starting material. Because it comes from TCI, an established reagent brand, laboratories can match each lot to its documentation and keep their synthetic procedures reproducible.
- Asymmetric reduction studies: the ketone group can be reduced to a chiral alcohol, so it is a useful substrate for testing and comparing enantioselective reduction methods.
- Condensation reactions: the carbonyl group reacts with amines or other carbonyl compounds, so chemists can use it to make imines, enones and related intermediates for further synthesis.
- Heterocycle construction: the carbonyl group can be converted into various heterocyclic systems, so this non-heterocyclic building block is a practical entry point to ring-containing target molecules.
- Transition-metal-catalysed coupling: the aromatic chlorine at the ortho position can take part in metal-catalysed coupling reactions, which lets researchers attach new carbon or heteroatom substituents to the ring.
- Steric and electronic effect studies: the ortho chlorine affects nearby reactivity, which makes the compound useful for exploring how substitution patterns change reaction outcomes and selectivity.
| Brand | TCI (product code C1084) |
|---|---|
| CAS number | 2142-68-9 |
| Molecular formula | — |
| Purity | refer to the TCI certificate of analysis and product documentation |
| Category | Chemistry > Building Blocks > Non-Heterocyclic Building Blocks |
| Pack sizes | see the available options on the product page |
| Physical form | — |
| Storage | follow the storage conditions on the TCI label and safety data sheet |
Keep 2'-Chloroacetophenone in its original, tightly closed TCI container in a cool, dry, well-ventilated place, away from direct sunlight, heat sources and incompatible substances such as strong oxidising agents. Follow any storage temperature given on the product label or safety data sheet. Handle the material in a fume hood and wear suitable personal protective equipment, including chemical-resistant gloves, safety glasses and a lab coat. Avoid breathing vapour and avoid contact with skin and eyes. Read the safety data sheet before use, label all secondary containers clearly, and dispose of waste according to institutional and local regulations.
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