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Description
4'-Cyanoacetophenone (CAS 1443-80-7) from TCI is a bifunctional aromatic ketone carrying a para-positioned nitrile group. The acetyl moiety supports aldol condensations, chalcone formation, and heterocycle construction, while the nitrile can be hydrolysed, reduced, or converted into tetrazole rings. This dual reactivity makes it a practical starting point for medicinal chemistry and functional materials research. AMI Scientific offers the reagent in 10 g and 25 g pack sizes for laboratory use.
Scientific References
Reidlinger et al. (1999). ChemInform Abstract: Cyanoacetophenone as a Synthon for 1,4,5‐Substituted Pyrazoles.. ChemInformdoi:10.1002/chin.199909139
Reidlinger et al. (1998). Cyanoacetophenone as a Synthon for 1,4,5-Substituted Pyrazoles. Monatshefte für Chemie / Chemical Monthlydoi:10.1007/pl00010132
Park et al. (2017). A Novel Probe with a Chlorinated α-Cyanoacetophenone Acceptor Moiety Shows Near-Infrared Fluorescence Specific for Tau Fibrils. CHEMICAL & PHARMACEUTICAL BULLETINdoi:10.1248/cpb.c17-00559
References were compiled automatically from Crossref and every DOI was verified to exist. AMI Scientific is not affiliated with the authors or the publishers.
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