TCI C1258 1-Chloro-3,5-dimethoxybenzene (CAS 7051-16-3) is a symmetrically substituted aryl chloride that serves as a versatile non-heterocyclic building block. The aromatic chlorine provides a handle for palladium-catalyzed cross-coupling, while the two electron-donating methoxy groups can later be demethylated to reveal free phenols. Its 3,5-dimethoxyphenyl motif is central to stilbenoid, combretastatin, and resveratrol-analog chemistry, making it popular in natural product and medicinal chemistry research. AMI Scientific offers 10 g and 25 g pack sizes, and the material should be handled in a fume hood with standard laboratory protection.
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