Cortisone TCI C1317

Chemical Identity

Other names: 17alpha,21-Dihydroxypregn-4-ene-3,11,20-trione
CAS No.: 53-06-5
PubChem: CID 222786·SID 87566331
Formula: C21H28O5
Molecular weight: 360.45 g/mol
Purity: >97.0%(HPLC)
Reference databases: ChEBI·ChemSpider·ECHA·Wikipedia

Full identifiers (IUPAC, SMILES, InChIKey)

IUPAC: (8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthrene-3,11-dione
SMILES: CC12CCC(=O)C=C1CCC3C2C(=O)CC4(C3CCC4(C(=O)CO)O)C
InChIKey: MFYSYFVPBJMHGN-ZPOLXVRWSA-N
MDL: MDL00003610

Rp 2.332.050,00

~~Rp 1.646.400,00~~ Rp 2.332.050,00

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TCI C1317 Cortisone is a classic glucocorticoid steroid widely used as a biochemical reagent and reference compound in life science research. It is closely linked to cortisol through 11β-hydroxysteroid dehydrogenase activity, making it a common substrate in steroid metabolism studies. Laboratories also employ it as an analytical standard for HPLC and LC-MS hormone profiling and as a starting material for steroid derivatisation. AMI Scientific supplies this TCI product in a 1 g pack for research use only, and it should be stored cool, dry, and protected from light.

Advantages (TCI brochure)

Natural corticoid on which synthetic corticoids were developed

TCI brochures (PDF)

Bone Metabolism Research Reagents 2026-04-21 · p. 2
Steroids 2026-07-28 · p. 5
Immune System, Inflammation, Allergy Research Reagents 2025-05-26 · p. 2

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From the TCI brochure

Structural basis for synthetic corticoids

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Clinic for Ear, Nose and Throat Medicine, Bundeswehr Central Hospital, Germany et al. (2025). Intratympanic Cortisone Injection: An Evaluation of the Current Data Situation. International Journal of Health Policy Planning doi:10.33140/ijhpp.04.01.01
Alsop et al. (2016). The Lipid Bilayer Provides a Site for Cortisone Crystallization at High Cortisone Concentrations. Scientific Reports doi:10.1038/srep22425
Nomura et al. (1997). Circadian rhythms in plasma cortisone and cortisol and the cortisone/cortisol ratio. Clinica Chimica Acta doi:10.1016/s0009-8981(97)00142-3

References were compiled automatically from Crossref and every DOI was verified to exist. AMI Scientific is not affiliated with the authors or the publishers.