Prednisolone TCI P0637

Prednisolone from TCI (product code P0637) is a synthetic steroid hormone that belongs to the glucocorticoid class. Structurally, it is a derivative of cortisol (hydrocortisone) with an additional double bond in the A ring. In the laboratory, prednisolone serves as a pharmaceutical research reagent for experimental use. Because it activates the glucocorticoid receptor, it is an important tool in immunology, endocrinology, and cell biology research. It is also widely used as a reference compound in the chemical analysis of corticosteroid-based pharmaceutical preparations.

Researchers choose prednisolone because its anti-inflammatory and immunosuppressive activities are well documented, so experimental results can be compared readily with a large body of published literature. The compound acts through the intracellular glucocorticoid receptor and changes the expression of many genes involved in inflammation. This makes it a reliable positive control in anti-inflammatory assays. Its steroid structure contains a conjugated ketone group that gives a distinct UV absorbance, so it can be detected easily by HPLC-UV for quantification. Sourcing it from TCI, an established reagent brand, gives laboratories consistent material from batch to batch.

In Indonesia, pharmacology, biotechnology, and pharmaceutical chemistry laboratories at universities, research institutes, and the pharmaceutical industry use prednisolone in routine and exploratory work. Academic groups use it in cell-based studies of inflammation and immune response. Quality control and analytical laboratories use it as a comparison standard when developing or verifying chromatographic methods for corticosteroid products. Graduate research projects in pharmacy and biomedical science also often include prednisolone as a benchmark glucocorticoid against which new candidate compounds are evaluated.

• Anti-inflammatory assays: prednisolone acts as a reliable positive control because its activity on the glucocorticoid receptor and on inflammation-related gene expression is well documented.
• Immunology research: its established immunosuppressive effects let researchers study how immune cells respond to glucocorticoid signalling in controlled in vitro experiments.
• Endocrinology studies: as a synthetic glucocorticoid derived from cortisol, it helps researchers investigate steroid hormone receptor activation and the cellular responses that follow.
• HPLC-UV analysis of pharmaceuticals: the conjugated ketone group gives clear UV absorbance, which makes it a convenient reference compound for quantifying corticosteroid preparations.
• Cell biology and drug discovery: researchers use it as a benchmark compound when screening new anti-inflammatory candidates, so results can be compared directly with the extensive existing literature.

Keep prednisolone in its original, tightly closed container, away from moisture, heat, and direct light, and follow the storage temperature on the TCI label and Safety Data Sheet. Store it in a dedicated area for pharmaceutical research reagents, separate from incompatible chemicals. Because prednisolone is a biologically active glucocorticoid, wear gloves, a lab coat, and eye protection when handling it. Weigh the powder in a fume hood or ventilated balance enclosure so you don't inhale dust. Label any prepared solutions clearly with the concentration and date. Dispose of waste according to your institution's chemical waste procedures. This product is for research and experimental use only and is not for human or veterinary use.

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