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Description
TCI C1365 (S)-2-Chloro-3-methylbutyric Acid (CAS 26782-74-1) is an enantiomerically defined chiral building block bearing an alpha-chloro substituent next to a branched isopropyl group. The alpha-chlorine acts as an excellent leaving group in bimolecular nucleophilic substitution, proceeding with predictable inversion of configuration and giving access to unnatural amino acids and chiral alpha-hydroxy acids. The free carboxylic acid remains available for esterification, amidation, or reduction, allowing sequential elaboration of both functional groups. AMI Scientific offers this TCI chiral building block in 1 g and 5 g pack sizes for asymmetric synthesis research.
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