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Description
TCI C2077 is 2-Chloro-5-nitrophenol, a substituted phenol carrying a chlorine atom at the ortho position and a nitro group at the meta position relative to the hydroxyl group. As a non-heterocyclic building block, this compound offers three points of chemical manipulation within a single small molecule: a phenolic hydroxyl group that can be alkylated or acylated, a nitro group that can be reduced to an aromatic amine, and a chlorine atom that serves as an entry point for substitution reactions. That versatility is what makes it a popular starting material in the synthesis of heterocyclic compounds, dyes, and active ingredient intermediates.
The characteristic that drives its selection is the electronic influence of the two electron-withdrawing substituents on the ring. The nitro group strongly pulls electron density away from the aromatic system, which increases the acidity of the phenolic group and leaves the ring more susceptible to nucleophilic aromatic attack at the activated positions. At the same time, the nitro group functions as a highly valuable synthetic handle, because its reduction yields an aromatic amine — the gateway to the formation of benzoxazole and benzimidazole rings and other heterocyclic systems.
In Indonesian laboratories, this material belongs in the Chemistry > Building Blocks > Non-Heterocyclic Building Blocks category and is typically drawn on by synthetic and medicinal chemistry groups building intermediates step by step. As a coloured solid, nitrophenol compounds generally need to be protected during storage and handling. Work is normally carried out in a fume hood on a laboratory scale, with the container returned promptly to its designated storage location after each weighing.
Laboratory Applications
Heterocyclic synthesis: reduction of the nitro group delivers an aromatic amine that can be cyclised directly into benzoxazole, benzimidazole, and related heterocyclic ring systems.
Nucleophilic aromatic substitution studies: the electron-withdrawing nitro group activates the ring, so the chlorine atom becomes a practical leaving point for incoming nucleophiles.
Dye intermediate preparation: the substituted phenol framework is a recognised starting material in dye chemistry, where the nitro group also contributes to the chromophore.
Active ingredient intermediate work: three independently addressable functional groups in one small molecule allow chemists to assemble complex targets through short, controlled sequences.
Phenol derivatisation chemistry: the phenolic hydroxyl can be alkylated or acylated selectively, giving access to ethers and esters for further downstream transformations.
Specifications
Brand: TCI
CAS number: 619-10-3
Chemical name: 2-Chloro-5-nitrophenol
Category: Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
Physical form: coloured solid
Pack sizes: available in the pack sizes offered under the TCI catalogue code C2077
Storage: keep protected, as is generally required for nitrophenol compounds
Handling and Storage
Store the container tightly closed in a cool, dry, well-ventilated area away from direct light, heat sources, and incompatible reagents. Nitrophenol compounds generally need protection during storage, so keep the material in its original supplier container or an equivalent tightly sealed chemical-resistant bottle, clearly labelled with the compound name and CAS number. Handle the solid inside a fume hood to avoid inhaling dust, and wear a laboratory coat, chemical splash goggles, and suitable gloves. Weigh only the quantity required, close the container immediately afterwards, and return it to its designated storage location. Consult the supplier safety data sheet before first use and dispose of residues through the laboratory's chemical waste stream.
