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Description
TCI C2080 2-Chloro-5-fluorobenzonitrile is a substituted benzonitrile compound carrying two different halogen groups: a chlorine at the ortho position and a fluorine at the meta position relative to the cyano group. This material belongs to the family of fluorinated building blocks, small-molecule starting materials that chemists use to construct larger and more complex molecular frameworks. In organic synthesis laboratories, a compound of this type serves as a practical entry point because the three functional groups it contains — the nitrile, the aryl chloride, and the aryl fluoride — can each be directed toward a different chemical transformation according to the synthetic route a researcher has designed.
The characteristic that makes this material a frequent choice is its substitution pattern, which provides graded reactivity across the molecule. The cyano group is a strong electron-withdrawing substituent, so it activates the aromatic ring toward nucleophilic aromatic substitution, particularly at the position bearing the fluorine. The carbon–chlorine bond, by contrast, is better suited to transition-metal-catalysed cross-coupling reactions. The nitrile group itself is a versatile handle that can be converted into a primary amine, a carboxylic acid, an amide, or an aldehyde, giving the chemist several independent directions from a single starting material.
In Indonesian laboratories, materials of this kind are typically used in university and institutional organic synthesis groups, in medicinal and agrochemical research programmes, and in method development work where a defined halogenated intermediate is required. It is normally ordered as a research-scale starting material rather than a bulk commodity, drawn from stock as individual synthetic steps are planned, and handled alongside the coupling reagents, catalysts, and dry solvents that the associated reaction chemistry requires.
Laboratory Applications
- Nucleophilic aromatic substitution studies — the strongly electron-withdrawing cyano group activates the ring so that the fluorine position can be displaced by oxygen, nitrogen, or sulfur nucleophiles under controlled conditions.
- Transition-metal-catalysed cross-coupling — the carbon–chlorine bond provides a distinct handle for palladium- or nickel-mediated coupling chemistry, allowing new carbon–carbon or carbon–heteroatom bonds to be formed selectively.
- Medicinal chemistry scaffold construction — the fluorinated aromatic core is a recurring motif in drug discovery, and this building block lets researchers introduce that motif early in a synthetic sequence.
- Nitrile functional group transformations — the cyano group can be converted to primary amines, carboxylic acids, amides, or aldehydes, so a single compound supports several divergent downstream synthetic routes.
- Agrochemical and specialty intermediate research — halogenated benzonitriles serve as intermediates in developmental work where a defined substitution pattern must be carried through multiple reaction steps reliably.
Specifications
- Brand: TCI (Tokyo Chemical Industry)
- CAS number: 57381-56-3
- Product code: C2080
- Category: Chemistry > Building Blocks > Fluorinated Building Blocks
- Pack sizes: available in standard TCI research-scale packaging; please confirm the current pack options when ordering
- Storage: keep in a cool, dry place in the tightly closed original container
Handling and Storage
Store this material in its original tightly closed container in a cool, dry, well-ventilated area away from direct sunlight, moisture, and incompatible substances such as strong oxidising agents and strong bases. Amber or opaque containers with chemically resistant closures are appropriate, and the container should be reclosed promptly after each use to limit moisture uptake. Handle inside a fume hood using safety glasses, chemically resistant gloves, and a laboratory coat, since benzonitrile derivatives should not be inhaled or allowed to contact skin and eyes. Weigh and transfer the compound with clean, dry glassware or spatulas to avoid cross-contamination, keep the label legible at all times, and consult the manufacturer's safety data sheet before first use for full hazard information and for waste disposal in accordance with local laboratory regulations.
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