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Description
TCI C2129 2-Chloro-4-fluorobenzonitrile is a halogenated aromatic compound that carries three functional groups on a single benzene ring: a nitrile group, a chlorine atom, and a fluorine atom. This combination makes it a highly valued starting material, or building block, in organic synthesis laboratories, particularly when a researcher needs to construct a branched molecular framework in stages. At the bench, this compound serves as a point of departure for forming substituted benzonitrile derivatives, heterocyclic precursors, and aromatic fragments that are later coupled into larger and more complex target molecules.
The characteristic that makes this material a frequent choice is the reactivity of its aromatic ring, which has been "activated" by the electron-withdrawing nitrile group. That condition makes the halogen atoms more readily displaced by nucleophiles such as amines, alkoxides, or thiolates through nucleophilic aromatic substitution reactions. The difference in reactivity between fluorine and chlorine also gives chemists the opportunity to carry out functionalization selectively and stepwise. In addition, the nitrile group itself can be transformed further into amides, carboxylic acids, primary amines, and other derivatives, which broadens the range of synthetic routes available from a single starting material.
In Indonesian laboratories, this compound is typically used in university research groups, organic synthesis laboratories, and pharmaceutical or agrochemical development units that build molecular candidates step by step. It is generally ordered in small research quantities for reaction screening, route optimization, and the preparation of intermediates for further study. Researchers usually work with it inside a fume hood as part of a planned multi-step synthesis, where a well-defined, reliably characterized building block shortens the path to the desired target structure.
Laboratory Applications
- Nucleophilic aromatic substitution studies: the electron-withdrawing nitrile activates the ring, so amines, alkoxides, and thiolates displace the halogen under practical laboratory conditions and reproducible reaction control.
- Selective stepwise functionalization: the reactivity difference between the fluorine and chlorine substituents lets chemists address one position first, then the other, building substitution patterns in a deliberate order.
- Heterocyclic precursor synthesis: the nitrile group and the activated halogenated ring together provide the reactive handles needed to close nitrogen-containing rings and related heterocyclic frameworks.
- Nitrile group transformations: the cyano function can be converted onward into amides, carboxylic acids, or primary amines, giving several downstream product classes from one common starting material.
- Aromatic fragment preparation for complex targets: substituted benzonitrile fragments prepared from this material are coupled into larger molecules during pharmaceutical and agrochemical research and development programs.
Specifications
- Brand: TCI (Tokyo Chemical Industry)
- Product code: C2129
- CAS number: 60702-69-4
- Chemical name: 2-Chloro-4-fluorobenzonitrile
- Category: Chemistry > Building Blocks > Fluorinated Building Blocks
- Pack sizes: available in standard research-scale packaging as listed for this catalogue item
- Storage: keep in a tightly closed original container, in a cool, dry, well-ventilated place
Handling and Storage
Store this compound in its original, tightly closed container in a cool, dry, and well-ventilated area, away from direct sunlight, heat sources, moisture, and incompatible materials such as strong oxidizing agents and strong bases. Amber glass or the manufacturer's supplied container is suitable; keep the closure secure to limit exposure to atmospheric moisture. Handle inside a fume hood, using nitrile gloves, safety goggles, and a laboratory coat, and avoid inhalation of dust and contact with skin or eyes. Weigh and transfer with clean, dry equipment, close the container immediately after use, and wash hands thoroughly afterwards. Dispose of residues and contaminated materials as chemical waste according to institutional procedures. Always consult the manufacturer's safety data sheet before use.
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