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Description
2-Chloroadenosine is a purine nucleoside analogue derived from adenosine through substitution of a chlorine atom at the 2-position of the adenine ring. Supplied by TCI under catalogue number C2192 and identified by CAS number 146-77-0, it is widely used as a pharmacological tool in the study of purinergic signalling. Researchers apply it in particular to examine adenosine receptor responses in nervous tissue, smooth muscle, and the cardiovascular system, where it serves as a dependable probe of receptor-mediated activity in both isolated preparations and cultured cell systems.
Within biochemistry and pharmacology laboratories, this compound functions as a reference ligand and comparison substance in receptor binding experiments, cell function assays, and the synthesis of more complex nucleoside derivatives intended for drug research. The principal characteristic that leads investigators to select 2-Chloroadenosine is the chloro group at position 2, which confers better metabolic stability against enzymatic degradation than natural adenosine. As a result, its effects can be observed across a longer and more reproducible experimental window, an advantage in protocols that require sustained receptor stimulation.
The material is also available as a crystalline solid that is straightforward to weigh accurately and to dissolve in aqueous solvents or dimethyl sulfoxide when preparing stock solutions. In Indonesian laboratories, this practical handling profile suits university research groups, pharmacology teaching laboratories, and institutional research centres that prepare working dilutions from concentrated stocks. As a TCI product, the compound is accompanied by lot analysis data that makes it easy to verify identity and confirm quality suitability before the material is used in experimental work.
Laboratory Applications
Purinergic signalling research: the compound acts as a stable agonist tool for probing how adenosine receptor pathways regulate cellular responses across different tissue preparations under controlled experimental conditions.
Receptor binding experiments: it serves as a reference ligand and comparison substance, allowing binding characteristics of test compounds to be evaluated against a well-established purine nucleoside analogue.
Neuropharmacology studies: researchers use it to examine adenosine receptor responses in nervous tissue, where its improved metabolic stability supports observations over extended incubation periods.
Smooth muscle and cardiovascular investigation: the material is applied to study receptor-mediated responses in smooth muscle and cardiovascular systems, providing reproducible stimulation throughout the assay window.
Nucleoside derivative synthesis: it functions as a starting material for preparing more complex nucleoside derivatives used in drug research programmes requiring defined and analytically verified precursors.
Specifications
Brand: TCI, catalogue number C2192
CAS number: 146-77-0
Category: Life Science > Biochemicals and Reagents > Nucleosides, Nucleotides, Oligonucleotides
Pack sizes: available in the standard TCI research pack presentations; please confirm the required size when ordering
Physical form: crystalline solid, readily weighed and dissolved in aqueous solvents or dimethyl sulfoxide
Documentation: supplied with TCI lot analysis data for identity and quality verification
Handling and Storage
Store the container tightly closed in a cool, dry place, protected from light and moisture, and follow the storage conditions stated on the product label and lot documentation. Keep the crystalline solid in its original tightly sealed container or in a clean amber glass vial, and allow the container to reach room temperature before opening to reduce condensation on the powder. Prepared stock solutions in aqueous buffer or dimethyl sulfoxide should be kept in sealed, clearly labelled vials and dispensed in aliquots to limit repeated freeze-thaw handling. Weigh and transfer the material in a well-ventilated area or fume hood, wearing a laboratory coat, safety glasses, and suitable gloves. Avoid generating dust, keep the compound away from incompatible substances, and consult the safety data sheet before use and for disposal guidance.
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