• 2-Chloroadenosine (CAS 146-77-0) - TCI C2192 - AMI Scientific
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TCI

CAS 146-77-0

2-Chloroadenosine TCI C2192

2-Chloroadenosine TCI C2192
Rp 477.750,00
Rp 477.750,00
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2-Chloroadenosine is an adenosine analog belonging to the nucleoside group of compounds, consisting of a purine base attached to a ribose sugar. In the laboratory, it is used primarily as a stable adenosine receptor agonist, allowing researchers to investigate a wide range of cellular signaling pathways mediated by the A1, A2A, A2B, and A3 receptor subtypes. Because its structure closely resembles natural adenosine, it functions as a reliable experimental tool for probing physiological responses such as the inhibition of platelet aggregation, effects on the nervous system, and regulation of specific enzyme activities. This product is supplied by TCI in analytical packaging under CAS number 146-77-0.

The main property that leads researchers to select 2-Chloroadenosine is its substantially better stability compared with ordinary adenosine. The presence of a chlorine atom at position two of the purine ring shields the molecule from rapid deamination by the enzyme adenosine deaminase, so its biological effects persist much longer in test systems. This extended resistance to enzymatic breakdown makes the compound especially valuable in assays where prolonged receptor stimulation is required, and it reduces the variability that can arise from the rapid degradation of native adenosine. The compound is generally available as a white to off-white crystalline solid, which is convenient for accurate weighing, dissolution, and the preparation of reproducible stock solutions.

In Indonesian laboratories, this compound is typically used in life science research focused on pharmacology, cell biology, and neuroscience. Academic institutions and research facilities working on receptor pharmacology commonly employ it to characterize adenosine receptor-mediated signaling in cultured cells and isolated tissues. It also appears in studies examining the regulation of enzyme activity and in experiments designed to evaluate the physiological role of adenosine signaling. In this way, it provides Indonesian researchers with a dependable and stable reference agonist for reproducible assays.

  • Adenosine receptor pharmacology studies: The compound acts as a stable agonist at the A1, A2A, A2B, and A3 receptors, enabling researchers to map signaling pathways with minimal interference from enzymatic degradation.
  • Platelet aggregation research: Because it inhibits platelet aggregation in a sustained manner, it is well suited for studying the role of adenosine signaling in hemostasis and thrombus formation in vitro.
  • Neuroscience and nervous system studies: Its resistance to deamination allows prolonged receptor stimulation, making it useful for investigating adenosine-mediated effects on neuronal activity and neurotransmission.
  • Enzyme activity regulation assays: The stable analog helps researchers examine how adenosine receptor activation modulates the activity of specific enzymes under controlled experimental conditions.
  • Signal transduction and cell physiology experiments: Researchers can use this compound to trigger long-lasting, reproducible responses in cell-based assays, supporting consistent data across repeated experimental runs.

Brand TCI
CAS number 146-77-0
Molecular formula —
Purity —
Category Life Science > Biochemicals and Reagents > Nucleosides, Nucleotides, Oligonucleotides
Pack sizes supplied in analytical packaging; refer to the product listing for available pack sizes
Physical form white to off-white crystalline solid
Storage —
  • Product code: C2192

Store the product in its original, tightly sealed container in a cool, dry place away from direct light and excessive moisture. Keep the container closed when not in use to protect the compound from humidity, which may affect its crystalline form. Always wear appropriate personal protective equipment, including laboratory gloves and safety glasses, when handling this material. Weigh out only the required amount for each experiment and avoid returning unused material to the original container to prevent contamination. Follow standard laboratory hygiene practices, label all working solutions clearly, and dispose of any waste in accordance with your institution's regulations.

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