Carnosic Acid (Synthetic) TCI C2488

Chemical Identity

Other names: (4aR,10aS)-5,6-Dihydroxy-7-isopropyl-1,1-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-4a-carboxylic Acid (Synthetic)
CAS No.: 3650-09-7
PubChem: CID 65126·SID 125307807
Formula: C20H28O4
Molecular weight: 332.44 g/mol
Purity: >97.0%(HPLC)(T)
Storage: <0°C
Reference databases: ChEBI·ChemSpider·ECHA·Wikipedia

Full identifiers (IUPAC, SMILES, InChIKey)

IUPAC: (4aR,10aS)-5,6-dihydroxy-1,1-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthrene-4a-carboxylic acid
SMILES: CC(C)C1=C(C(=C2C(=C1)CCC3C2(CCCC3(C)C)C(=O)O)O)O
InChIKey: QRYRORQUOLYVBU-VBKZILBWSA-N
MDL: MDL02259459

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Carnosic Acid (TCI C2488) is a synthetic compound widely used in scientific research, particularly in biochemical and pharmacological studies. Derived from sage leaves, this compound plays a crucial role in laboratories where researchers investigate antioxidant, anti-inflammatory, and pharmacological properties. Its molecular structure is complex, making it a valuable reagent for various experimental applications. Carnosic Acid is commonly used as a building block in the synthesis of other compounds or as a test material in studies related to health and environmental science. Its chemical stability and solubility in organic solvents make it a versatile choice for a wide range of experimental procedures.

This compound is preferred due to its chemical stability, solubility in organic solvents, and consistent purity. Its ability to interact with free radicals makes it ideal for assessing antioxidant activity in chemical reactions and biological systems. The availability of Carnosic Acid in pure form and precise concentrations ensures accuracy and reliability in research settings. These properties make it a reliable and essential component in many laboratory protocols, especially those involving oxidative stress studies and pharmacological testing.

In Indonesian laboratories, Carnosic Acid is frequently used in research related to health, environmental science, and pharmacology. It is a common material in studies focused on natural products, drug development, and bioactive compound analysis. Its role in assessing antioxidant and anti-inflammatory effects supports its use in both academic and industrial research environments. The compound’s versatility and reliability make it a preferred choice for researchers seeking precise and reproducible results.

Advantages (TCI brochure)

Produced by chemical synthesis
Main antioxidative substance of rosemary

TCI brochures (PDF)

Carnosic Acid 2024-08-15 · p. 1
Antioxidants for Research and Experimental Use 2026-07-29 · p. 1
Traditional Medicine/Crude Medicine Research Reagents 2024-09-11 · p. 1
Terpenes 2025-09-22 · p. 8
Plant Research Reagents 2026-02-24 · p. 8
Phytochemicals 2025-12-17 · p. 6

Related TCI products

Antioxidant Activity Testing: Carnosic Acid is used to evaluate the scavenging ability of free radicals in biological and chemical systems.
Pharmacological Research: It serves as a key reagent in studies investigating the therapeutic potential of natural compounds.
Environmental Toxicology Studies: Carnosic Acid helps assess the impact of pollutants on biological systems and oxidative stress.
Drug Development and Synthesis: It is used as a building block in the synthesis of novel compounds with potential therapeutic applications.
Bioactive Compound Analysis: It is employed in the identification and quantification of bioactive components in plant extracts and natural products.

From the TCI brochure

Skin-whitening effect
Prevention of arterial embolism
Prevention of hyperlipidemia
Lowering glucose level

Brand	TCI
CAS number	3650-09-7
Molecular formula	—
Purity	—
Category	Life Science > Biochemicals and Reagents > Crude Medicine Ingredients for Research and Experimental Use
Pack sizes	Available in various quantities as per standard laboratory requirements
Physical form	Solid powder
Storage	Store in a cool, dry place away from light and moisture

Data from the TCI brochure

Ukuran kemasan	20 mg / 100 mg
Metode produksi	Sintesis kimia (Synthetic)

Source: TCI brochure LL012 (2024-08-15)

Carnosic Acid should be stored in a cool, dry place, away from direct light and moisture to maintain its chemical stability. It is recommended to use airtight containers made of glass or polyethylene to prevent contamination and degradation. Due to its organic nature, it should be handled with care, using appropriate personal protective equipment such as gloves and safety goggles. It is important to ensure that the storage area is well-ventilated to minimize exposure to airborne particles. Regular monitoring of storage conditions is advised to maintain the integrity of the compound for experimental use. Proper labeling and safe handling procedures are essential to prevent accidental spills or contamination in the laboratory environment.

References cited in the TCI brochure

Masahiro Tada. Syntheses of Carnosic Acid and Carnosol, Anti-oxidants in Rosemary, from Pisiferic Acid, the Major Constituent of Sawara Chemical and Pharmaceutical Bulletin, 2010. doi:10.1248/cpb.58.27
Toshiyuki Takahashi. Carnosic acid and carnosol inhibit adipocyte differentiation in mouse 3T3-L1 cells through induction of phase2 enzymes and activation of glutathione metabolism Biochemical and Biophysical Research Communications, 2009. doi:10.1016/j.bbrc.2009.03.059
Daniel Poeckel. Carnosic acid and carnosol potently inhibit human 5-lipoxygenase and suppress pro-inflammatory responses of stimulated human polymorphonuclear leukocytes Biochemical Pharmacology, 2008. doi:10.1016/j.bcp.2008.04.013
Kiyofumi Ninomiya. Carnosic acid, a new class of lipid absorption inhibitor from sage Bioorganic & Medicinal Chemistry Letters, 2004. doi:10.1016/j.bmcl.2004.01.091
Ying Zhang. Oxidative stability of sunflower oil supplemented with carnosic acid compared with synthetic antioxidants during accelerated storage Food Chemistry, 2010. doi:10.1016/j.foodchem.2009.05.038