2,4-Dichlorobenzoyl Chloride TCI D0345

Chemical Identity

CAS No.: 89-75-8
PubChem: CID 66645·SID 87567036
Formula: C7H3Cl3O
Molecular weight: 209.45 g/mol
Purity: >97.0%(GC)(T)
Reference databases: ECHA

Full identifiers (IUPAC, SMILES, InChIKey)

IUPAC: 2,4-dichlorobenzoyl chloride
SMILES: C1=CC(=C(C=C1Cl)Cl)C(=O)Cl
InChIKey: CEOCVKWBUWKBKA-UHFFFAOYSA-N
MDL: MDL00000661

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2,4-Dichlorobenzoyl Chloride from TCI is an aromatic acyl chloride, the reactive derivative of 2,4-dichlorobenzoic acid. As a non-heterocyclic building block, it serves as an acylating reagent for introducing the 2,4-dichlorobenzoyl group into other molecules. With this reagent, researchers can prepare amides, esters, ketones, and anhydrides. The dichlorobenzoyl group appears fairly often in pharmaceutical intermediates, agrochemicals, and polymerization initiators, which gives this reagent an important role in applied synthesis.

Its main advantage is the high reactivity of the acyl chloride group. This group reacts quickly with amines, alcohols, and phenols, usually at room temperature with a base present to capture the HCl released. As a result, acylation proceeds efficiently without additional coupling reagents, which simplifies workup and reduces reagent costs per step. The chlorine atoms on the aromatic ring increase the electrophilicity of the carbonyl carbon and give the resulting products lipophilic character. The compound can also be used in Friedel-Crafts acylation to form chlorine-substituted aryl ketones.

In Indonesian laboratories, 2,4-Dichlorobenzoyl Chloride is needed in medicinal chemistry research to build amide and ester libraries, in agrochemical process development, and in polymer research involving initiator synthesis. University organic synthesis groups, pharmaceutical research and development units, and industrial process laboratories all benefit from a dependable source of this TCI building block. Having the reagent on hand lets them run acylation steps directly instead of first activating the parent carboxylic acid.

Related TCI products

Amide library synthesis: the acyl chloride reacts rapidly with primary and secondary amines at room temperature, so researchers can prepare many 2,4-dichlorobenzamide analogues without coupling reagents.
Ester preparation: alcohols and phenols are acylated efficiently with a base scavenging the HCl, which gives a straightforward route to 2,4-dichlorobenzoate esters for structure-activity studies.
Friedel-Crafts acylation: the reagent can acylate aromatic substrates to form chlorine-substituted aryl ketones, which are useful intermediates for further functionalization in multistep synthesis.
Agrochemical intermediate development: the dichlorobenzoyl group appears in agrochemical intermediates, so this reagent helps process chemists introduce that structural motif directly and efficiently.
Polymerization initiator research: dichlorobenzoyl groups are found in polymerization initiators, which makes this compound a practical starting material for laboratories that synthesize and study initiator systems.

Brand	TCI (product code D0345)
CAS number	89-75-8
Molecular formula	—
Purity	—
Category	Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
Pack sizes	refer to the available options on the product page
Physical form	—
Storage	keep tightly sealed and protected from moisture, as stated on the TCI label and SDS

Chemical class: aromatic acyl chloride, derived from 2,4-dichlorobenzoic acid

Like other acyl chlorides, 2,4-Dichlorobenzoyl Chloride reacts with water and atmospheric moisture to release hydrogen chloride, so the container should be kept tightly closed in a cool, dry, well-ventilated area away from water, alcohols, amines, and bases. Keep it in the original TCI container or in a well-sealed glass bottle with a chemically resistant cap. Inert-gas blanketing helps preserve quality after the container has been opened. Handle the reagent inside a fume hood while wearing chemical-resistant gloves, safety goggles, and a lab coat, because it is corrosive to skin, eyes, and the respiratory tract. Add it slowly to reaction mixtures and keep an HCl-scavenging base available. Always read the supplier's Safety Data Sheet before use, and dispose of residues according to local laboratory waste regulations.

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