• 1,4-Diformylpiperazine (CAS 4164-39-0) - TCI D2578 - AMI Scientific
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TCI

CAS 4164-39-0

1,4-Diformylpiperazine TCI D2578

1,4-Diformylpiperazine TCI D2578
Rp 1.741.950,00
Rp 1.741.950,00
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TCI D2578 1,4-Diformylpiperazine is a heterocyclic building block consisting of a piperazine ring in which both nitrogen atoms have been formylated to give two formamide groups. The compound is important in organic synthesis laboratories because piperazine is one of the most frequently encountered heterocyclic scaffolds in drug molecules, while the diformyl form offers a practical way to handle, protect, or make use of the ring. This material serves both as a synthetic intermediate and as a source of formyl groups in a number of organic transformations.

The characteristic that makes this compound a preferred choice is the nature of its formamide groups, which are simultaneously stable and removable. The formyl groups mask the basicity and nucleophilicity of the piperazine nitrogens, so the ring does not interfere with reactions carried out on other parts of the molecule, yet they can be hydrolysed back when the free amine is required, under either acidic or basic conditions. The solid form is also easier to weigh and handle than free piperazine, which is hygroscopic and strongly basic. The formamide linkages in this compound are additionally exploited as a formyl source or isocyanide precursor in synthesis.

In Indonesian laboratories, this building block is typically used in university and institutional research groups working on organic synthesis and medicinal chemistry, where piperazine-containing targets are common. It is also relevant for laboratories preparing reference materials and intermediates on a small scale, and for teaching laboratories illustrating protecting group strategies. Because it is supplied as a TCI catalogue item, it fits research settings that require a documented, catalogue-referenced building block rather than a locally prepared reagent.

  • Piperazine protection strategies — the two formamide groups mask both ring nitrogens, allowing chemists to run reactions elsewhere in a molecule without competing amine reactivity, then deprotect afterwards.
  • Medicinal chemistry intermediate synthesis — piperazine is one of the most common scaffolds in drug molecules, so this pre-formylated ring gives a convenient entry point for building such structures.
  • Formyl group donor in organic transformations — the formamide linkages can act as a source of formyl functionality, letting the compound serve as a reagent rather than only a skeleton.
  • Isocyanide precursor chemistry — the formamide bonds in this compound are exploited as isocyanide precursors, supporting synthetic routes that require this class of reactive intermediate.
  • Handling replacement for free piperazine — as a solid, it is easier to weigh accurately and dispense than hygroscopic, strongly basic free piperazine in routine bench-scale work.

Brand TCI (Tokyo Chemical Industry)
CAS number 4164-39-0
Molecular formula —
Purity —
Category Chemistry > Building Blocks > Heterocyclic Building Blocks
Pack sizes available in TCI standard research-scale pack sizes; please confirm the size required when ordering
Physical form —
Storage store in a tightly closed container in a cool, dry place, following the manufacturer's product documentation
  • Catalogue number: D2578
  • Chemical name: 1,4-Diformylpiperazine

Store 1,4-Diformylpiperazine in its original tightly closed container, kept in a cool, dry, and well-ventilated place away from moisture, heat, and incompatible materials such as strong acids and strong bases, which can hydrolyse the formamide groups. Amber glass or the supplier's original packaging is suitable; transfer only what is needed and reseal promptly to limit moisture uptake. Handle the solid in a fume hood or well-ventilated area, using gloves, safety glasses, and a laboratory coat, and avoid generating or inhaling dust. Weigh with clean, dry spatulas to prevent cross-contamination. Always consult the manufacturer's safety data sheet before use, and dispose of residues and contaminated materials through your institution's chemical waste procedures.

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