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Description
TCI D2595 2,3-Difluoroaniline is a fluorinated building block consisting of an aniline ring bearing two adjacent fluorine atoms at the 2 and 3 positions. This compound occupies an important place in modern synthetic chemistry because it combines a highly reactive aromatic amino group with a specific fluorination pattern. The amino group serves as a starting point for the formation of amides, sulfonamides, ureas, diazonium salts, and a wide range of heterocyclic ring systems, while the fluorine atoms fundamentally alter the electronic character of the molecule and influence the physicochemical properties of the final products that researchers design around it.
The property that makes this compound a preferred choice is the distinctive influence of the fluorine atoms themselves. Fluorine is strongly electronegative yet small in size, so its substitution lowers the basicity of the amino group, increases stability against oxidative metabolism, and tunes the lipophilicity of the molecule without adding meaningful steric bulk. The placement of two neighbouring fluorine atoms also directs subsequent substitution reactions toward particular positions on the ring, giving chemists a valuable degree of regiochemical control over the transformations they carry out.
As a liquid at room temperature, this compound is easily transferred with a micropipette or a syringe, which makes it convenient in the working routines of Indonesian laboratories. It is typically used in university research groups, pharmaceutical and agrochemical development laboratories, and materials chemistry laboratories, where a fluorinated aniline is required as an intermediate for exploratory synthesis, method development, and small-scale preparation of target molecules before any scale-up is considered.
Laboratory Applications
Amide and sulfonamide synthesis: the free aromatic amino group reacts readily with acyl chlorides and sulfonyl chlorides, making this a direct entry point to fluorinated amide scaffolds.
Heterocycle construction: the aniline nitrogen can be incorporated into a variety of heterocyclic ring systems, allowing researchers to build fluorinated cores for medicinal chemistry programmes.
Diazonium salt chemistry: the amino group can be converted into a diazonium salt, which opens access to further ring functionalisation and to a broad family of downstream derivatives.
Pharmaceutical intermediate preparation: the fluorination pattern lowers amine basicity and improves resistance to oxidative metabolism, properties that are frequently sought in drug candidate design.
Agrochemical and materials research: adjacent fluorine substitution tunes lipophilicity and electronic character without steric penalty, which suits the design of new active ingredients and functional materials.
Specifications
Brand: TCI (Tokyo Chemical Industry)
CAS Number: 4519-40-8
Product Code: D2595
Category: Chemistry > Building Blocks > Fluorinated Building Blocks
Physical form: liquid at room temperature
Pack sizes: available in standard TCI catalogue pack sizes; please confirm the required size when ordering
Storage: keep in a tightly closed container in a cool, well-ventilated area away from light
Handling and Storage
Store the container tightly closed in a cool, dry, and well-ventilated place, protected from direct sunlight and away from oxidising agents and sources of ignition. The original manufacturer bottle is the most suitable container; if transfer is necessary, use chemically compatible glassware with a secure closure and label it clearly. Because the material is a liquid, dispense it with a micropipette or syringe inside a fume hood to limit vapour exposure. Wear nitrile gloves, safety goggles, and a laboratory coat during handling, avoid contact with skin and eyes, and consult the manufacturer's safety data sheet before use. Keep spill absorbents and an eyewash station accessible in the working area.
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