3,5-Dichlorophenylhydrazine Hydrochloride TCI D2644

Name: TCI D2644 63352-99-8 3,5-Dichlorophenylhydrazine Hydrochloride
Brand: TCI
SKU: TCI2510D264422945
Price: 2038050.0 IDR
Availability: InStock

Rp 2.038.050,00

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Berat 5g 25g

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Description

TCI D2644 3,5-Dichlorophenylhydrazine Hydrochloride with CAS number 63352-99-8 is a chlorinated arylhydrazine supplied as its hydrochloride salt, with both chlorine atoms occupying the meta positions symmetrically arranged with respect to the hydrazine group. The material belongs to the non-heterocyclic building block family and serves as a key starting material for constructing nitrogen-containing rings. In synthetic laboratory work, the hydrazine group reacts rapidly with carbonyl compounds to form hydrazones, and those hydrazones can subsequently be cyclized into indole, pyrazole, indazole, or triazole rings, so a single reagent opens access to several classes of heterocyclic compounds at once.

The characteristic that makes this reagent an attractive choice is the symmetry of its 3,5-substitution pattern. Because both positions ortho to the hydrazine group remain unoccupied while both meta positions are equally substituted, ring closure in the Fischer indole synthesis proceeds with a more predictable regiochemical outcome than with unsymmetrical isomers. The two chlorine atoms are electron-withdrawing, which lowers the electron density of the aromatic ring and influences both the rate and the direction of reaction, while in the final product the same two chlorine atoms remain reactive handles that can be developed further. Supply as the hydrochloride salt also gives the free hydrazine base a more convenient, easier-to-handle form for weighing and storage.

In Indonesian laboratories, this building block is typically used in university and institutional research groups working on organic synthesis and medicinal chemistry, where substituted heterocyclic scaffolds are prepared on a milligram-to-gram scale. It is also relevant to method development groups that need a defined arylhydrazine for hydrazone derivatization or for exploratory route-scouting work. Because it arrives as a catalogue reagent from TCI, it fits laboratories that require a consistently identified starting material for reproducible multi-step sequences.

Laboratory Applications

Fischer indole synthesis: the symmetrical 3,5-dichloro pattern leaves both ortho positions free, so cyclization onto the ring gives a more predictable regiochemical outcome than unsymmetrical arylhydrazine isomers.
Hydrazone formation from aldehydes and ketones: the hydrazine group reacts rapidly with carbonyl compounds, making this reagent useful for preparing isolable hydrazone intermediates or for carbonyl derivatization studies.
Pyrazole ring construction: hydrazones and related condensation products derived from this arylhydrazine can be closed to pyrazole cores that carry the dichlorophenyl group already installed on nitrogen.
Indazole and triazole scaffold preparation: the same hydrazine handle supports cyclization routes into indazole and triazole rings, letting one starting material serve several heterocyclic target classes.
Medicinal chemistry route scouting: the retained chlorine atoms act as reactive handles for further elaboration in the final product, so analogue series can be extended after the heterocyclic core is formed.

Specifications

Brand: TCI (Tokyo Chemical Industry)
CAS number: 63352-99-8
Chemical name: 3,5-Dichlorophenylhydrazine Hydrochloride
Catalogue number: D2644
Category: Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
Pack sizes: available in the standard catalogue pack sizes offered for this product; please confirm the required pack size when ordering
Storage: keep in the tightly closed original container, protected from moisture and light

Handling and Storage

Store the container tightly closed in a cool, dry, and well-ventilated area, away from light, moisture, and sources of ignition, and keep it separated from strong oxidizing agents. The original supplier container is the most suitable primary packaging; if transfer is necessary, use a clean, dry, tightly sealing glass or other chemically compatible container that is clearly labelled with the compound name and CAS number. Handle the solid in a fume hood, weigh it carefully to limit dust generation, and wear a laboratory coat, chemical-resistant gloves, and eye protection. Close the container immediately after each use, avoid contact with skin and eyes, wash hands after handling, and consult the manufacturer's Safety Data Sheet before use and for waste disposal guidance.