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CAS 41100-52-1

3,5-Dimethyl-1-adamantanamine Hydrochloride TCI D3608

3,5-Dimethyl-1-adamantanamine Hydrochloride TCI D3608
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Description

3,5-Dimethyl-1-adamantanamine Hydrochloride is the hydrochloride salt of a primary amine attached to a doubly methylated adamantane framework. The adamantane structure is a three-dimensional hydrocarbon cage that is highly rigid and symmetrical, while the amine group at position one provides a clearly defined reactive site. The compound is classified as a non-heterocyclic building block and is used in laboratories as a synthetic starting material, an analytical reference material, and a substance for pharmacological study, since aminoadamantane derivatives are widely recognised in central nervous system research.

The hydrochloride salt form is the principal reason this product is selected. The free amine of the adamantane framework is strongly lipophilic and tends to absorb carbon dioxide from the air, whereas the salt form is a stable solid that has no sharp odour, is easy to weigh accurately, and is far more soluble in water and polar solvents. These properties make the preparation of standard solutions for chromatographic analysis and biological experiments considerably easier. The adamantane cage also imparts a characteristic conformational rigidity and steric hindrance, so its derivatives tend to be more resistant to metabolic degradation.

In Indonesian laboratories this material is typically handled in organic synthesis groups, analytical chemistry units, and pharmacological research facilities at universities, government research institutes, and industrial development laboratories. It is generally used at small to medium scale, where accurate weighing of a stable crystalline salt matters more than bulk quantity. Working solutions are commonly prepared fresh in aqueous or polar solvent systems, then applied directly in synthetic reactions, reference standard preparation, or screening studies.

Laboratory Applications

  • Organic synthesis starting material: the well-defined primary amine site allows straightforward amidation, alkylation, and condensation reactions onto a rigid adamantane cage scaffold.
  • Analytical reference material: the stable, easily weighed salt form supports the preparation of accurate standard solutions for chromatographic identification and quantification work.
  • Pharmacological research: aminoadamantane derivatives are widely studied in central nervous system research, making this compound useful for investigative and comparative studies.
  • Medicinal chemistry scaffold work: the conformational rigidity and steric hindrance of the adamantane framework help derivatives resist metabolic degradation in structure-activity studies.
  • Method development and validation: high solubility in water and polar solvents simplifies preparation of working solutions for repeated instrument calibration and method verification runs.

Specifications

  • Brand: TCI
  • CAS Number: 41100-52-1
  • Category: Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
  • Pack sizes: available in standard TCI catalogue research-scale pack sizes; please confirm the required size when ordering
  • Physical form: solid hydrochloride salt
  • Storage note: keep tightly closed in a cool, dry place away from moisture

Handling and Storage

Store the container tightly closed in a cool, dry, well-ventilated area, protected from moisture and direct sunlight. Original manufacturer packaging or a tightly sealed glass or chemically compatible plastic container is suitable; reseal immediately after each use to limit moisture uptake by the salt. Handle in a fume hood or a well-ventilated workspace and wear standard laboratory personal protective equipment, including a lab coat, safety glasses, and chemical-resistant gloves. Avoid generating dust during weighing, avoid contact with skin and eyes, and wash hands thoroughly after handling. Keep the material separated from strong oxidising agents and strong acids, label all prepared solutions clearly, and dispose of residues and contaminated materials according to institutional chemical waste procedures. Always consult the manufacturer safety data sheet before use.

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