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Description
TCI D3625 2,6-Dichloro-4-fluoroaniline is a substituted aniline compound carrying two chloro groups at the ortho positions and one fluoro group at the para position relative to the aromatic amine group. This material is classified as a fluorinated building block, meaning a starting material used by organic synthesis laboratories to assemble larger molecular frameworks. Its role in the laboratory is to serve as a source of a benzene ring that has already been halogenated in a controlled manner, so that researchers do not need to carry out the halogenation step themselves, a step that is normally difficult to direct toward a specific position. In this way, the compound shortens the synthetic route and improves the reproducibility of experimental results.
The main characteristic that makes this compound a preferred choice is its highly specific and pre-arranged substitution pattern on the aromatic ring. The primary amine group provides a reaction site that is readily modified through acylation, sulfonylation, alkylation, or diazotization, while the chlorine and fluorine atoms govern the electron density of the ring and determine the direction of subsequent reactions. The presence of fluorine is also frequently exploited to modify lipophilicity, metabolic stability, and hydrogen bonding strength in the target molecules being developed. Because this substitution pattern is fixed at the raw material stage, laboratories obtain a consistent starting point from one batch to the next.
In Indonesian laboratories, this type of fluorinated building block is typically used in university research groups, pharmaceutical and agrochemical development laboratories, and contract research units that carry out multi-step organic synthesis. It is generally ordered in small quantities appropriate to bench-scale exploratory work, where a well-defined halogenated intermediate saves time and reduces the number of purification steps. Supplying it as a ready-made TCI catalogue item also simplifies procurement planning for laboratories that need a dependable and repeatable synthetic starting material.
Laboratory Applications
- Pharmaceutical intermediate synthesis: the primary amine and fixed halogen pattern allow controlled elaboration into larger drug-like scaffolds without an additional halogenation step in the route.
- Agrochemical research: the combination of chloro and fluoro substituents on the aromatic ring provides an electronically tuned core commonly explored in the development of active compounds.
- Diazotization chemistry: the aromatic primary amine can be converted into a diazonium species, opening access to substitution and coupling reactions that install further functional groups.
- Amide and sulfonamide preparation: acylation or sulfonylation of the amine group gives derivatives quickly, making the material useful for building small screening libraries in research laboratories.
- Structure–activity relationship studies: the fluorine atom lets researchers adjust lipophilicity, metabolic stability, and hydrogen bonding strength while keeping the rest of the molecular framework unchanged.
Specifications
- Brand: TCI
- Catalogue number: D3625
- CAS number: 344-19-4
- Chemical name: 2,6-Dichloro-4-fluoroaniline
- Category: Chemistry > Building Blocks > Fluorinated Building Blocks
- Pack sizes: available in standard TCI research and bench-scale catalogue pack sizes; please confirm the size required when ordering
- Storage: store in a closed original container under the conditions stated on the manufacturer label and safety data sheet
Handling and Storage
Store the container tightly closed in a cool, dry, and well-ventilated area, away from direct sunlight, heat sources, and incompatible chemicals such as strong oxidizing agents. Keep the material in its original manufacturer container, or in a clean, chemically compatible and clearly labelled alternative, and reseal it promptly after each use to limit exposure to air and moisture. Handle inside a fume hood using appropriate personal protective equipment, including safety goggles, chemically resistant gloves, and a laboratory coat. Avoid inhalation of dust or vapour and avoid contact with skin and eyes. Always consult the manufacturer safety data sheet before use, and dispose of residues and contaminated materials in accordance with applicable chemical waste procedures.
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