Dibenzo[b,f][1,4]thiazepin-11(10H)-one TCI D3693

Name: TCI D3693 3159-07-7 Dibenzo[b,f][1,4]thiazepin-11(10H)-one
Brand: TCI
SKU: TCI2510D369324048
Price: 1949850.0 IDR
Availability: InStock

Rp 1.949.850,00

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Berat 25g

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Description

TCI D3693 Dibenzo[b,f][1,4]thiazepin-11(10H)-one is a heterocyclic building block composed of two benzene rings fused to a seven-membered thiazepine core containing both a sulfur and a nitrogen atom, with a lactam carbonyl group at position 11. This tricyclic framework is an important structural core in medicinal chemistry, particularly within the dibenzothiazepine class of compounds. In the laboratory, the material serves as a primary starting material for constructing dibenzothiazepine derivatives through activation of the lactam group, replacement of the oxygen atom, and introduction of side chains at the nitrogen atom or at carbon positions on the core.

The property that makes this material a preferred choice is its fully formed and stable heterocyclic framework, which means researchers do not need to carry out the seven-membered ring formation step that is normally the most difficult and lowest-yielding stage in a synthetic route. The lactam group provides a clearly defined reactive handle for a range of transformations, for example chlorination to the corresponding imino chloride derivative, which is subsequently reacted with amines. Its solid form is straightforward to weigh and handle, and the rigid, electron-rich aromatic framework adds further appeal.

In Indonesian laboratories, this building block is typically used in university and institutional research settings where synthetic and medicinal chemistry work is carried out on a bench scale. It is generally handled in fume-hood synthesis, weighed out in small quantities for reaction screening and route development, and applied in postgraduate research projects that require a reliable, pre-formed heterocyclic core rather than a lengthy in-house ring construction sequence. The rigid aromatic framework also draws interest from materials-oriented research groups.

Laboratory Applications

Dibenzothiazepine derivative synthesis: the pre-formed tricyclic core lets researchers begin directly at the derivatisation stage instead of first building the difficult seven-membered thiazepine ring.
Lactam activation chemistry: the carbonyl group at position 11 offers a clearly defined reactive site for chlorination to imino chloride intermediates that are subsequently coupled with amines.
Medicinal chemistry scaffold work: as a recognised structural core in medicinal chemistry, it supports the preparation of analogue series built around the dibenzothiazepine framework for structure-activity studies.
Nitrogen and carbon side-chain installation: the framework accommodates insertion of side chains at the ring nitrogen atom or at core carbon positions, allowing systematic variation of substitution patterns.
Materials-oriented research: the rigid, electron-rich aromatic framework makes the compound of interest to groups investigating structurally defined heteroaromatic systems in materials applications.

Specifications

Brand: TCI
CAS number: 3159-07-7
Product code: D3693
Category: Chemistry > Building Blocks > Heterocyclic Building Blocks
Physical form: solid, easy to weigh and handle
Pack sizes: available in the standard TCI catalogue pack sizes; please confirm the required size when ordering
Storage: keep in the tightly closed original container as indicated on the manufacturer label

Handling and Storage

Store the material in its tightly closed original container, kept in a cool, dry and well-ventilated area away from direct sunlight, moisture and incompatible substances. Amber glass or the supplier's original packaging is suitable for keeping the solid protected and clearly identified. Weighing and transfer should be carried out in a fume hood using clean, dry spatulas to avoid cross-contamination, and the container should be closed again immediately after use. Standard laboratory personal protective equipment applies: a lab coat, safety glasses and chemical-resistant gloves. Avoid dust formation and inhalation, do not eat or drink in the working area, and wash hands thoroughly after handling. Always consult the manufacturer's Safety Data Sheet before use, and dispose of residues and contaminated materials in accordance with applicable chemical waste procedures.