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Description
TCI D3697 3,5-Dimethyl-1-adamantanol is a tertiary alcohol built on the adamantane framework — a saturated cage structure that is highly rigid and symmetrical — carrying two additional methyl groups at the 3 and 5 positions and a single hydroxyl group on a bridge carbon. In the organic synthesis laboratory, this compound serves as a non-heterocyclic building block, meaning it is used as a starting scaffold that is subsequently modified into a target molecule. Its role appears mainly in medicinal chemistry research and active pharmaceutical ingredient development, where the adamantane motif is exploited to tune the physicochemical properties of the final molecule.
The characteristics that make researchers select this compound are the combination of a strongly lipophilic hydrocarbon framework and a single reactive point in the form of a tertiary alcohol. The adamantane cage imparts conformational rigidity, so the position of the functional group is relatively locked in space — an advantage when researchers want to control molecular geometry. The tertiary hydroxyl group ionizes readily to give a reasonably stable carbonium cation, which makes this compound a practical entry point for substitution, amination, and etherification reactions.
In Indonesian laboratories, material of this kind is typically handled in university and institutional research groups working on medicinal chemistry and pharmaceutical ingredient development, as well as in synthesis groups that need a defined, well-characterized scaffold rather than a mixture. It is normally ordered in research-scale quantities for stepwise synthetic route development, method optimization, and analog preparation, then stored and dispensed under the laboratory's routine chemical inventory controls.
Laboratory Applications
- Medicinal chemistry scaffold work — the rigid adamantane cage locks the functional group position in space, letting researchers control the geometry of candidate molecules during analog design.
- Active pharmaceutical ingredient development — the adamantane motif is used to tune the physicochemical properties of the final molecule, particularly its lipophilic character in the finished structure.
- Nucleophilic substitution reactions — the tertiary hydroxyl ionizes readily into a reasonably stable carbonium cation, making it a practical and convenient entry point for substitution chemistry.
- Amination routes — the single reactive tertiary alcohol site provides one clearly defined point of attack, so amination proceeds toward the intended product without competing functional groups.
- Etherification and further derivatization — the bridge-carbon hydroxyl allows the cage to be elaborated into ethers and other derivatives while the saturated framework itself remains intact.
Specifications
- Brand: TCI
- CAS number: 707-37-9
- Catalogue reference: D3697
- Category: Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
- Pack sizes: available in standard TCI research-scale packaging; please confirm the pack size when ordering
- Storage: keep in a tightly closed original container in a cool, dry, well-ventilated place, following the manufacturer's label instructions
Handling and Storage
Store the material in its original, tightly closed container in a cool, dry, well-ventilated area, away from heat, direct sunlight, ignition sources, and incompatible reagents such as strong oxidizing agents. Keep containers clearly labelled and recorded in the laboratory chemical inventory. Handle in a fume hood using appropriate personal protective equipment — safety glasses, chemical-resistant gloves, and a laboratory coat — and avoid generating dust or inhaling any airborne particles. Weigh and transfer using clean, dry glassware or compatible plasticware, and close the container promptly after use to limit moisture uptake. Wash hands after handling, dispose of residues and contaminated materials as chemical waste according to institutional procedures, and always consult the manufacturer's Safety Data Sheet before first use.
