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Description
TCI D4137 2'-Deoxyadenosine Anhydrous is a purine nucleoside composed of an adenine base linked to a 2'-deoxyribose sugar. It is one of the fundamental building blocks of DNA, which makes it a core reagent across biochemistry, molecular biology, and nucleic acid chemistry laboratories. The anhydrous form indicates that the material contains no water of crystallization, so mass can be weighed out directly without applying a correction for water content. Its principal laboratory roles include serving as a starting material for chemical synthesis, as a media component, and as a reference standard in nucleoside analysis.
The property that makes this nucleoside a widely preferred choice is a chemical structure that is already organized for further modification. The hydroxyl groups at the 5' and 3' positions of the deoxyribose sugar can be protected, phosphorylated, or selectively coupled, while the amino group on the adenine base offers a separate derivatization route. The absence of a hydroxyl group at the 2' position distinguishes it from ribo-adenosine and makes it the appropriate starting material for DNA chemistry. Purity and batch-to-batch consistency from an established reagent supplier matter greatly here, because impurities present in a nucleoside can propagate through subsequent steps of a synthesis or an assay.
In Indonesian laboratories, this nucleoside is typically encountered in university and institutional research settings working on nucleic acid chemistry, in molecular biology groups preparing or characterizing DNA-related materials, and in analytical laboratories that need a defined nucleoside as a comparison standard. It is also used in synthetic chemistry laboratories where modified deoxynucleosides are prepared step by step. Because it is supplied as a defined reagent-grade material, it fits routine bench work where consistent identity and handling are expected.
Laboratory Applications
- Chemical synthesis starting material: the 5' and 3' hydroxyl groups and the adenine amino group provide defined, selectively addressable positions for protection, phosphorylation, and coupling in multi-step deoxynucleoside chemistry.
- Nucleic acid and DNA chemistry research: as a basic DNA building block lacking the 2' hydroxyl group, it is the structurally correct precursor for work directed at deoxyribonucleotide rather than ribonucleotide systems.
- Reference standard in nucleoside analysis: a defined, consistent nucleoside is required as a comparison material when identifying or comparing nucleoside peaks and responses in analytical laboratory workflows.
- Media and formulation component: the compound is used as a nucleoside component in prepared laboratory media, where the anhydrous form simplifies direct weighing without correcting for water of crystallization.
- Biochemistry and molecular biology teaching or method development: it serves as a fundamental, well-characterized nucleoside for building, validating, and demonstrating nucleic acid related laboratory procedures and preparations.
Specifications
- Brand: TCI
- CAS number: 958-09-8
- Category: Life Science > Biochemicals and Reagents > Nucleosides, Nucleotides, Oligonucleotides
- Product code: D4137
- Form: anhydrous (contains no water of crystallization)
- Pack sizes: available in the manufacturer's standard catalogue pack sizes; please confirm the required pack size when ordering
- Storage: store according to the manufacturer's stated conditions on the product label and safety data sheet
Handling and Storage
Store the container tightly closed in a cool, dry place, away from moisture, direct sunlight, and sources of heat, and follow the storage conditions stated by the manufacturer on the product label and safety data sheet. Keep the material in its original supplier container, or in a clean, well-sealed, chemically compatible container that is clearly labelled with the product name and CAS number. Because the anhydrous form is intended to be weighed without a water correction, minimise exposure to atmospheric humidity by closing the container promptly after use and allowing refrigerated material to reach room temperature before opening. Handle with standard laboratory precautions: wear a laboratory coat, safety glasses, and suitable gloves, weigh and transfer the solid in a well-ventilated area or fume hood to avoid dust inhalation, use clean spatulas to prevent cross-contamination between batches, and consult the safety data sheet before use and disposal.
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