TCI
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Description
TCI D4689, with CAS number 141625-93-6, is Dronedarone Hydrochloride, a benzofuran-derived compound supplied as a reagent for pharmaceutical research and experimental laboratory use. Dronedarone is known in the literature as an antiarrhythmic compound that is structurally related to amiodarone but does not contain iodine atoms, carrying instead an additional methanesulfonamide group on its benzofuran framework. As a hydrochloride salt, the material is offered to laboratories that require a defined reference compound for medicinal chemistry and pharmacological investigation rather than for clinical or therapeutic application.
In its hydrochloride salt form, this compound offers more practical handling and better solubility in certain aqueous media than its free base. The properties that make the hydrochloride form a widely preferred choice are its stability and its consistency as a salt solid that can be weighed accurately, so that the preparation of stock solutions for in vitro assays can be carried out with good reproducibility. Its molecular structure, containing a benzofuran ring, a sulfonamide group, and a dibutylamino side chain, provides several points of study at once, ranging from structure–activity relationships to the behaviour of the molecule under different experimental conditions.
In Indonesian laboratories, this material is used as a test substance, an analytical reference material, and an object of study in medicinal chemistry and pharmacology research. It typically serves university research groups, pharmaceutical research and development units, and analytical laboratories that need a well-defined benzofuran-derived compound for experimental work. Its use is confined to research and experimental settings, where a consistent solid reference supports method development and comparative study across repeated experiments.
Laboratory Applications
- Medicinal chemistry research — the benzofuran core, sulfonamide group, and dibutylamino side chain give researchers several distinct structural features to examine within a single, well-defined molecule.
- Structure–activity relationship studies — its close structural relationship to amiodarone, without iodine atoms, makes it a useful comparison point when investigating how structural modifications influence compound behaviour.
- Pharmacological research — as an antiarrhythmic compound described in the literature, it serves as a study object for experimental pharmacology work carried out entirely under laboratory conditions.
- Analytical reference material — the consistency of the hydrochloride salt as a weighable solid supports its use as a comparison standard during analytical method development and verification work.
- In vitro assay preparation — improved solubility in certain aqueous media and accurate weighability allow stock solutions to be prepared with good reproducibility across repeated experimental runs.
Specifications
- Brand: TCI
- CAS Number: 141625-93-6
- Chemical name: Dronedarone Hydrochloride, a benzofuran derivative
- Category: Life Science > Biochemicals and Reagents > Pharmaceutical Research Reagents (for Experimental Use)
- Physical form: solid, supplied as the hydrochloride salt
- Intended use: research reagent and analytical reference for experimental laboratory use only
- Pack sizes: available in the packaging options offered by the manufacturer; please confirm the required size when ordering
Handling and Storage
Store this reagent in its original tightly closed container, kept in a cool, dry place away from direct sunlight, moisture, and incompatible materials, and follow the storage conditions stated on the manufacturer's label and safety data sheet. Chemically resistant, well-sealed containers with clear and intact labelling are appropriate for both storage and any aliquots prepared in the laboratory. Handle the material in a well-ventilated area or fume hood using standard personal protective equipment, including a laboratory coat, gloves, and eye protection, and avoid generating or inhaling dust when weighing the solid. Because this material is intended for research and experimental use only, it should be handled exclusively by trained personnel, recorded in laboratory inventory, and disposed of in accordance with applicable institutional and local chemical waste procedures.
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