2-(2,2-Dimethyl-1,3-dioxolan-4-yl)ethan-1-ol TCI D5914

Name: TCI D5914 5754-34-7 2-(2,2-Dimethyl-1,3-dioxolan-4-yl)ethan-1-ol
Brand: TCI
SKU: TCI2510D591426903
Price: 2008650.0 IDR
Availability: InStock

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Berat 1g 5g

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Description

TCI D5914, CAS 5754-34-7, is 2-(2,2-Dimethyl-1,3-dioxolan-4-yl)ethan-1-ol, a compound that combines a free hydroxyl group with a diol already protected as an acetonide in the form of a 1,3-dioxolane ring. The material serves as a highly useful non-heterocyclic building block for researchers who need to modify one hydroxyl group selectively while the two remaining hydroxyl groups stay protected. In the laboratory, this compound is widely used as a doubly functionalised three-carbon chain precursor in the construction of polyol frameworks, lipids, and a range of target molecules that require stepwise control of functional groups.

The characteristic that makes this reagent a preferred choice is its practical and readily reversible protection strategy. The acetonide group is stable under basic and neutral conditions and towards many organometallic reagents as well as reducing agents, yet it can be removed easily under aqueous acidic conditions to reveal the vicinal diol once again. The remaining primary hydroxyl group shows normal reactivity, so it is ready to be converted into a tosylate, mesylate, halide, aldehyde, carboxylic acid, ester, or ether through well-established reactions. Being a liquid at room temperature, it is convenient to transfer and measure by volume.

In Indonesian laboratories, this building block is typically used in university synthetic chemistry research groups, natural product and medicinal chemistry programmes, and industrial R&D units that develop fine chemicals. It suits multi-step synthesis work where a protected diol must be carried through several transformations before deprotection at a later stage. Because it is supplied by TCI in standard research pack sizes, it fits both small-scale exploratory reactions and repeat preparations in teaching and research settings.

Laboratory Applications

Polyol framework synthesis: the protected vicinal diol lets researchers extend the carbon chain from the free hydroxyl end and unmask the diol only at the final stage.
Lipid and glycerol derivative preparation: the acetonide-protected glycerol-type motif provides a ready three-carbon unit for building lipid side chains with controlled regiochemistry.
Selective functional group manipulation: the single free primary hydroxyl allows tosylation, mesylation, or halogenation without competing reaction at the masked diol positions.
Oxidation to aldehyde or acid intermediates: the primary alcohol can be oxidised under standard conditions while the acetonide ring remains intact for subsequent coupling steps.
Multi-step medicinal chemistry intermediates: its stability towards organometallic and reducing reagents makes it suitable for sequences involving Grignard additions, reductions, and later acidic deprotection.

Specifications

Brand: TCI (Tokyo Chemical Industry)
CAS number: 5754-34-7
Chemical name: 2-(2,2-Dimethyl-1,3-dioxolan-4-yl)ethan-1-ol
Category: Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
Physical form: liquid at room temperature
Pack sizes: available in TCI standard research pack sizes; please confirm the current option when ordering
Storage: keep in a tightly closed container, protected from moisture and acidic vapours

Handling and Storage

Store the container tightly closed in a cool, dry, well-ventilated area away from acids and acidic vapours, since the acetonide protecting group is cleaved under aqueous acidic conditions. Keep the material in its original glass or otherwise compatible container, and avoid prolonged exposure to air and atmospheric moisture during transfer; use dry syringes or pipettes for aliquoting the liquid. Handle in a fume hood while wearing safety goggles, gloves, and a laboratory coat, and follow the supplier's safety data sheet for full precautions. Segregate from strong oxidising agents, label all working solutions clearly, and dispose of residues and contaminated materials through the laboratory's chemical waste channel in line with institutional procedures.