TCI
3'-O-[tert-Butyl(dimethyl)silyl]thymidine TCI D5997
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Description
3'-O-[tert-Butyl(dimethyl)silyl]thymidine is a chemical compound widely used in chemical biology, particularly in the study of nucleic acids. It belongs to the class of nucleotide analogs, which are structurally similar to DNA and RNA but with specific chemical modifications. This compound is commonly employed in laboratory settings as a building block for the synthesis of more complex molecules, including nucleotide analogs and enzyme inhibitors. Its unique structure allows it to be a versatile tool in various biochemical and pharmaceutical research applications.
The compound's chemical stability and resistance to unwanted reactions make it a preferred choice for synthetic processes. The tert-Butyl(dimethyl)silyl group at the 3' position acts as a protective group, preventing premature chemical reactions and ensuring the compound remains intact during synthesis. This property enhances its utility in controlled laboratory environments where precision and reliability are essential. Additionally, its solubility in organic solvents facilitates its use in purification and reaction processes.
In Indonesian laboratories, this compound is frequently used in biochemistry, pharmacology, and genetics research. Researchers in educational institutions and research centers rely on it to study enzyme mechanisms, synthesize complex molecules, and explore potential therapeutic applications. Its role in advancing scientific understanding in these fields is significant and well-established.
Laboratory Applications
- Biochemical synthesis of nucleotide analogs due to its stable structure and reactivity control.
- Enzyme inhibition studies as a model compound for understanding nucleotide interactions.
- Genetic research for designing modified nucleic acids and DNA/RNA analogs.
- Pharmaceutical development to create novel therapeutic agents targeting nucleic acid pathways.
- Analytical chemistry for use in nucleic acid hybridization and molecular probe applications.
Specifications
- Brand: TCI
- CAS number: 40733-27-5
- Category: Chemistry > Chemical Biology > Nucleic Acid Chemistry
- Pack sizes: Available in various quantities as per standard laboratory supply
- Physical form: Solid powder
- Storage note: Store in a cool, dry place away from light and moisture
Handling and Storage
This compound should be stored in a cool, dry environment, away from direct light and moisture to maintain its chemical integrity. It is recommended to use airtight containers made of glass or high-density polyethylene to prevent contamination and degradation. Due to its organic nature, it should be handled in a well-ventilated area, and appropriate personal protective equipment such as gloves and safety goggles should be worn. Avoid exposure to incompatible substances and ensure proper disposal according to local regulations. Regular monitoring of storage conditions is advised to ensure the compound remains suitable for use in laboratory applications.
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