2-Ethoxythiazole TCI E0669

Name: TCI E0669 15679-19-3 2-Ethoxythiazole
Brand: TCI
SKU: TCI2510E066928434
Price: 1034250.0 IDR
Availability: InStock

Rp 1.034.250,00

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Berat 5g 25g

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Description

2-Ethoxythiazole from TCI is a five-membered heterocyclic compound containing both a nitrogen atom and a sulfur atom within a single ring, with an ethoxy group attached at the two position, the site located between the two heteroatoms. The thiazole ring is one of the most important heterocyclic cores in biological and pharmaceutical chemistry, appearing in vitamin B1 as well as in a large number of active pharmaceutical ingredients. The role of this compound in the laboratory is that of a heterocyclic building block, allowing researchers to carry a complete thiazole core into a target molecule without having to construct the ring from scratch.

The property that governs its selection is the influence of the ethoxy group on the behaviour of the ring. Alkoxy groups push electron density into the aromatic system, raising the electron density at the five position and directing both substitution and metalation reactions towards particular positions in a relatively predictable manner. The ethoxy group at the two position can also act as a leaving group under certain conditions, opening up substitution pathways with amines or other nucleophiles. In addition, alkoxy-substituted thiazoles are known aroma compounds that contribute nutty and roasted nuances, which makes the material relevant to laboratories working in that field as well.

In Indonesian laboratories, this building block is typically encountered in synthetic organic chemistry groups at universities and research institutes, in medicinal chemistry programmes assembling thiazole-containing candidate structures, and in flavour and fragrance work where roasted and nutty character is under study. It is generally purchased in small research quantities, handled at the bench within a fume hood, and drawn upon as an intermediate rather than as a bulk process chemical.

Laboratory Applications

Heterocyclic scaffold introduction — the intact thiazole ring is delivered in one step, sparing the researcher a multi-step ring construction sequence and shortening the route to a target molecule.
Regioselective functionalisation studies — the electron-donating ethoxy group raises electron density at the five position, so substitution and metalation can be directed there with relatively predictable outcomes.
Nucleophilic substitution chemistry — under suitable conditions the two-position ethoxy group behaves as a leaving group, allowing amines and other nucleophiles to install new substituents on the ring.
Medicinal chemistry intermediate work — because the thiazole core appears in vitamin B1 and many active pharmaceutical ingredients, this material serves as an entry point into biologically relevant analogue series.
Flavour and aroma research — alkoxy-substituted thiazoles are recognised aroma compounds with nutty and roasted nuances, making this reagent useful to laboratories characterising such sensory contributions.

Specifications

Brand: TCI (Tokyo Chemical Industry)
CAS number: 15679-19-3
Category: Chemistry > Building Blocks > Heterocyclic Building Blocks
Product code: E0669
Pack sizes: supplied in standard TCI research pack sizes; please confirm the available options when ordering
Storage: keep in the tightly closed original container, protected from light and moisture, in accordance with the manufacturer's stated conditions

Handling and Storage

Store the material in its tightly closed original container, kept in a cool, dry and well-ventilated area away from direct sunlight, heat sources, ignition sources and strong oxidising agents. Compatible glass containers with tight-sealing caps are appropriate, and the container should be reclosed promptly after each use to limit exposure to air and moisture. Handle inside a working fume hood, wearing safety goggles, chemical-resistant gloves and a laboratory coat. Avoid inhalation of vapours and contact with skin and eyes. As with any organic building block bearing a sulfur-containing heterocycle, an odour may be noticeable, so ventilation should be verified before opening. Always consult the manufacturer's safety data sheet before use, and dispose of residues and contaminated materials through the laboratory's chemical waste stream.