TCI M1753 2-Methoxythiazole is a five-membered heterocyclic compound containing both nitrogen and sulfur atoms within a single ring, with a methoxy group attached at the 2-position. The thiazole ring is one of the most important heterocyclic scaffolds in organic and medicinal chemistry, appearing in a wide range of natural products as well as active pharmaceutical ingredients. As a heterocyclic building block, this compound supplies a ready-made core that saves the ring-formation steps, allowing researchers to focus directly on installing functional groups according to the design of their target molecules.
The property that makes this compound attractive is the electronic pattern of the thiazole ring combined with the electron-donating methoxy group. The methoxy group at the 2-position raises the electron density of the ring, which in turn influences the regioselectivity of metalation and substitution reactions at the 4- and 5-positions. The ring nitrogen atom is weakly basic and can coordinate to transition metals, a property that proves useful in ligand design and catalysis. The methoxy group can also act as a leaving group under certain conditions, opening routes toward 2-amino or 2-thio-thiazole derivatives.
In Indonesian laboratories, this building block is typically used in synthetic organic chemistry groups at universities and research institutes, as well as in the research and development units of pharmaceutical and agrochemical companies. It supports exploratory synthesis work where the thiazole core must be elaborated into more complex structures, and it is equally suited to teaching and postgraduate research laboratories that need a dependable heterocyclic starting material of consistent supplier origin.
Related TCI products
- Medicinal chemistry scaffold preparation, because the thiazole ring occurs widely in active pharmaceutical ingredients and gives chemists a validated core to elaborate into candidate structures.
- Heterocyclic synthesis route development, since the pre-formed ring removes the cyclization step and lets researchers begin directly at the functionalization stage of their planned sequence.
- Regioselective metalation and substitution studies, because the electron-donating methoxy group at position 2 shapes reactivity at positions 4 and 5 in a predictable pattern.
- Ligand design and coordination chemistry work, as the weakly basic ring nitrogen can coordinate to transition metals and thereby support catalyst and complex development studies.
- Preparation of 2-amino and 2-thio-thiazole derivatives, since the methoxy group can serve as a leaving group under appropriate conditions to give access to those substituted analogues.
| Brand | TCI |
|---|---|
| CAS number | 14542-13-3 |
| Molecular formula | — |
| Purity | — |
| Category | Chemistry > Building Blocks > Heterocyclic Building Blocks |
| Pack sizes | available in the standard research-scale pack sizes offered by the manufacturer for this catalogue item |
| Physical form | — |
| Storage | store according to the conditions stated on the manufacturer label and the accompanying safety data sheet |
- Chemical name: 2-Methoxythiazole
Store this building block in a tightly closed original container in a cool, dry and well-ventilated area, away from direct sunlight, heat sources and incompatible chemicals, following the storage conditions stated on the manufacturer label and safety data sheet. Keep the container properly closed between uses to limit exposure to moisture and air. Handle the material inside a functioning fume hood and wear suitable personal protective equipment, including safety goggles, chemical-resistant gloves and a laboratory coat. Use clean, dry glassware and dedicated spatulas when transferring the material to avoid cross-contamination. Label all secondary containers clearly, avoid generating vapours or aerosols, and dispose of residues and contaminated items according to applicable laboratory waste procedures. Consult the full safety data sheet before first use.
—
Produk Terkait
-
2-Ethoxythiazole TCI E0669
Regular price From Rp 928.200,00Regular price -
3-Methoxythiophene TCI M1093
Regular price From Rp 530.250,00Regular price -
2-Methoxythiophene TCI M1030
Regular price From Rp 2.147.250,00Regular price -
3,4-Dimethoxythiophene TCI D2728
Regular price From Rp 1.565.550,00Regular price -
N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine TCI B3087
Regular price From Rp 2.016.000,00Regular price -
5-MethoxytryptamineHydrochloride TCI M3563
Regular price Rp 1.298.850,00Regular price -
6-Methoxytryptamine TCI M3162
Regular price From Rp 2.889.600,00Regular price -
5-Methoxytryptamine TCI M0131
Regular price From Rp 477.750,00Regular price
