Ethosuximide TCI E0746

Name: TCI E0746 77-67-8 Ethosuximide
Brand: TCI
SKU: TCI2510E074628512
Price: 2186100.0 IDR
Availability: InStock

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Berat 5g 25g

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Description

TCI E0746 Ethosuximide (CAS 77-67-8) is a succinimide-class compound supplied by Tokyo Chemical Industry as a pharmaceutical research reagent intended for experimental use. Ethosuximide is widely recognised as an anticonvulsant agent that acts on T-type calcium channels in thalamic neurons, and for this reason it has become one of the most important reference compounds in neuropharmacology research, particularly in studies of absence seizures. In the laboratory, this material is used as a comparator compound in in vitro pharmacological assays and in animal studies, as an analytical standard for the development of assay methods, and as a reference material in formulation research.

The characteristics that make this compound a researcher's choice centre on its structure and its physicochemical behaviour. The succinimide ring, substituted with ethyl and methyl groups, yields a small, neutral and relatively chemically resistant molecule, so it is easy to handle and stable under ordinary storage conditions. Its small molecular size and moderate polarity allow the compound to dissolve in water to an adequate degree while also being able to cross the blood-brain barrier — the very property that underlies its usefulness in central nervous system research.

In Indonesian laboratories, this reagent is typically encountered in university pharmacology and pharmacy departments, in research institutes working on neuroscience, and in analytical laboratories developing and validating assay methods. Because it serves as a well-established reference point, it is generally used in comparative experimental work rather than in routine testing, supporting teaching laboratories, thesis and postgraduate research, and method development programmes that require a dependable succinimide standard for experimental purposes.

Laboratory Applications

Neuropharmacology screening studies — serves as an established reference anticonvulsant acting on T-type calcium channels, giving researchers a dependable comparator against which new candidate compounds can be judged.
Absence seizure research models — as one of the most important reference compounds in this specific field, it provides the expected pharmacological response needed to validate an experimental model.
In vitro pharmacological assays — its small, neutral molecular structure and adequate aqueous solubility make it straightforward to prepare and dose in cell-based and tissue-based comparative experiments.
Analytical method development — used as an analytical standard for building and refining assay methods for content determination, where its chemical stability supports reproducible calibration work over time.
Formulation research studies — acts as a reference material in preparation and formulation investigations, since its moderate polarity and chemical resistance let it survive typical processing and handling steps.

Specifications

Brand: TCI (Tokyo Chemical Industry)
CAS number: 77-67-8
Catalogue number: E0746
Category: Life Science > Biochemicals and Reagents > Pharmaceutical Research Reagents (for Experimental Use)
Pack sizes: available in standard TCI research packaging; please confirm the size required when ordering
Storage: stable under ordinary storage conditions in a closed container

Handling and Storage

Store the container tightly closed in a cool, dry place away from direct sunlight, moisture and incompatible chemicals. The compound is relatively chemically resistant and stable under ordinary storage conditions, so a well-sealed original container or an amber glass vessel with a chemically resistant closure is normally sufficient. Handle in a well-ventilated area or a fume hood, and wear a laboratory coat, safety glasses and suitable gloves when weighing or preparing solutions. Avoid generating dust, and use clean, dry spatulas and glassware to prevent contamination of the stock. Label all prepared solutions clearly with the compound name, CAS number and preparation date. This material is intended for experimental laboratory use only and should be handled by trained personnel following the supplier's safety data sheet and local institutional waste-disposal procedures.