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Description
Entacapone is a chemical compound widely used in pharmacological and biochemical research. As a key component in Parkinson’s disease treatment, it enhances the effectiveness of levodopa by inhibiting the enzyme COMT (catechol-O-methyltransferase). This compound plays a vital role in laboratories where researchers study neuropharmacology, drug metabolism, and neurodegenerative diseases. Its presence allows for the investigation of drug mechanisms and their impact on the nervous system. Entacapone is essential for experimental studies that require precise chemical interactions and controlled biological responses.
Entacapone is preferred due to its stable chemical properties under specific conditions, ensuring safe storage and use. It is a colorless, solid compound, which simplifies weighing and processing in laboratory settings. The high purity of this pharmaceutical ingredient makes it suitable for experiments demanding accuracy and reproducibility. Its chemical stability and consistent physical form contribute to its reliability in research applications. These characteristics make it a trusted choice for scientists working on drug development and therapeutic studies.
In Indonesian laboratories, entacapone is commonly used in Parkinson’s disease research, drug development, and pharmacokinetic studies. Its role in enhancing the efficacy of levodopa makes it a critical reagent for neuropharmacological investigations. Researchers in Indonesia rely on entacapone for its consistent performance and compliance with pharmaceutical standards. Its application supports both academic and industrial research efforts in the field of neuroscience and medicinal chemistry.
Laboratory Applications
Neuropharmacological research benefits from entacapone's ability to inhibit COMT, enhancing the study of dopaminergic pathways and drug efficacy.
Drug metabolism studies utilize entacapone to analyze how levodopa is processed in the body and how its effectiveness is influenced by enzyme activity.
Parkinson’s disease research leverages entacapone to explore therapeutic strategies and evaluate the impact of COMT inhibition on motor function.
Pharmacokinetic experiments use entacapone to assess drug absorption, distribution, and elimination in experimental models.
Neurodegenerative disease studies incorporate entacapone to investigate the role of COMT in the progression of neurological disorders and potential therapeutic interventions.
Specifications
Brand: TCI
CAS number: 130929-57-6
Category: Pharmaceutical Ingredients (for Research and Experimental Use)
Pack sizes: Not specified in the provided data
Physical form: Solid
Storage note: Store in a cool, dry place away from light
Handling and Storage
Entacapone should be stored in a cool, dry environment, away from direct light to maintain its chemical stability. It is recommended to use airtight containers to prevent moisture absorption and contamination. Due to its pharmaceutical nature, it should be handled with care to avoid exposure to incompatible substances. Laboratory personnel should wear appropriate personal protective equipment when handling this compound. Proper labeling of storage containers is essential for safety and traceability. Regular monitoring of storage conditions ensures the compound remains in optimal condition for research use.
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