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Description
Eltrombopag is a bioactive small molecule known as a non-peptide agonist of the thrombopoietin receptor, the c-Mpl receptor that governs platelet formation from megakaryocytes. Unlike natural thrombopoietin, which is a protein, this compound acts on the transmembrane domain of the receptor, which makes it an interesting research tool for studying the activation mechanisms of cytokine receptors. In the laboratory setting, the material is used as a research reagent in studies of hematopoiesis, blood stem cell biology, and signal transduction, where a defined chemical agonist is required in place of a recombinant protein ligand.
The properties that lead researchers to select this compound are its selectivity and its distinctive mechanism of action. Eltrombopag is able to trigger the JAK2 and STAT5 signaling pathways in cells expressing the thrombopoietin receptor, allowing investigators to observe megakaryocyte differentiation in a controlled manner within culture systems. The compound is also known for its ability to bind metal ions, particularly iron, which has become a research topic in its own right in studies of cellular iron metabolism. As a small molecule, the material dissolves readily in polar organic solvents for the preparation of stock solutions and is easier to store than protein-based reagents.
Laboratories in Indonesia use this material in cell biology and life science research work, where it supports experiments on blood cell formation and receptor signaling. Its stability as a small molecule suits laboratory conditions in which frequent handling and repeated preparation of working solutions from a stock are part of routine practice, and it reduces the cold-chain burden associated with protein reagents in academic, hospital, and institutional research settings across the country.
Laboratory Applications
Hematopoiesis research: the compound acts on the thrombopoietin receptor that regulates platelet formation, giving researchers a defined chemical means of stimulating this pathway in experimental systems.
Blood stem cell biology studies: as a non-peptide agonist it allows controlled stimulation of c-Mpl-expressing cells, supporting investigations into how progenitor populations respond to receptor activation.
Signal transduction analysis: the material triggers JAK2 and STAT5 pathways in receptor-expressing cells, making it suitable for experiments that trace cytokine receptor signaling cascades.
Megakaryocyte differentiation assays: researchers can observe differentiation in culture systems in a controlled manner, since the small molecule can be dosed precisely from a prepared stock solution.
Cellular iron metabolism research: the known capacity of this compound to bind metal ions, particularly iron, makes it relevant to studies examining iron handling within cells.
Specifications
Brand: TCI
Catalog number: E1578
CAS number: 496775-61-2
Category: Life Science > Cell Biology > Bioactive Small Molecules
Physical form: small molecule compound, soluble in polar organic solvents for stock solution preparation
Pack sizes: available in research-scale packaging; please confirm the current pack options when ordering
Storage: store according to the manufacturer's stated conditions on the product label
Handling and Storage
Store the container in a cool, dry place away from direct sunlight and follow the storage conditions stated by the manufacturer on the product label. Keep the material in its original tightly closed container, or in a chemically compatible amber glass or polypropylene vial when aliquoting stock solutions, and label all aliquots clearly with the compound name and preparation date. Handle the compound in a fume hood or well-ventilated area, wearing a laboratory coat, safety glasses, and suitable gloves. Because this is a bioactive research compound, avoid inhalation of powder, skin contact, and ingestion, and restrict use to trained laboratory personnel for research purposes only. Note that the metal-binding character of this compound means contact with metal surfaces and metal-containing solutions should be considered when preparing and storing solutions. Dispose of residues and contaminated consumables through the laboratory's chemical waste procedures.
