Prucalopride from TCI is a pharmaceutical research compound known as a selective serotonin 5-HT4 receptor agonist. In the laboratory it serves as a reference material and a pharmacological tool for studying serotonergic signalling pathways, especially those linked to gastrointestinal motility. Its mechanism of action is widely discussed in the scientific literature, so researchers often use prucalopride as a comparator compound when testing new drug candidates that target the same receptor. This product is intended only for research and experimental use. It is not for clinical use in humans or animals.
The main reason researchers choose prucalopride is its selectivity for the 5-HT4 receptor over other serotonin receptor subtypes. Because of this selectivity, effects seen in an experiment can be attributed to activation of that receptor with greater confidence. Its chemical structure, based on a benzofuran carboxamide scaffold, also makes it a useful example in structure–activity relationship studies. TCI supplies it in milligram pack sizes, so laboratories can obtain material with a clearly defined chemical identity, which supports reproducible and well-documented results.
In Indonesian laboratories, prucalopride is typically used by university pharmacology and pharmacy departments, biomedical research groups, and institutions working on drug discovery. Researchers studying gastrointestinal physiology, receptor pharmacology, or medicinal chemistry can use it as an established 5-HT4 reference agonist in their experimental designs. Milligram quantities suit small-scale in vitro work, method development, and comparison studies. Laboratories can get a well-characterised compound from a recognised reagent manufacturer without having to synthesise or purify it themselves.
- Serotonin receptor pharmacology studies: As a selective 5-HT4 receptor agonist, prucalopride lets researchers probe this receptor subtype specifically, with less interference from other serotonin receptors in the experimental system.
- Gastrointestinal motility research: Its documented role in serotonergic pathways linked to gut motility makes it a suitable tool for experimental models that study the mechanisms of gastrointestinal function.
- Reference compound in drug candidate screening: Its mechanism of action is well described in the literature, so it works as a comparator when evaluating new compounds that target the 5-HT4 receptor.
- Structure–activity relationship studies: Its benzofuran carboxamide structure provides a useful example for medicinal chemists who are exploring how structural features affect receptor selectivity and activity.
- Teaching and method development in pharmacology: Its clear chemical identity and well-documented receptor profile make it suitable for training researchers and for validating assay protocols in receptor pharmacology laboratories.
| Brand | TCI (product code P2467) |
|---|---|
| CAS number | 179474-81-8 |
| Molecular formula | — |
| Purity | — |
| Category | Life Science > Biochemicals and Reagents > Pharmaceutical Research Reagents (for Experimental Use) |
| Pack sizes | Milligram pack sizes (check current pack options with AMI Scientific) |
| Physical form | Refer to the TCI product documentation and Certificate of Analysis |
| Storage | Follow the storage conditions on the TCI label and Safety Data Sheet |
Store prucalopride in its original, tightly closed container under the conditions stated on the TCI label and Safety Data Sheet (SDS). Research compounds like this are generally kept in a cool, dry place away from direct light, moisture, and incompatible substances. After opening, reseal the container promptly to protect the material from humidity and contamination. Handle it only in a properly equipped laboratory, wearing suitable personal protective equipment such as a lab coat, gloves, and safety glasses. Weigh the powder carefully to avoid creating dust, and work in a fume hood or ventilated enclosure where appropriate. Label all prepared solutions clearly with the compound name, concentration, and date. Dispose of waste according to institutional and local regulations. This product is for research use only and must not be used in humans or animals.
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Product Categories
- Biochemicals and ReagentsPharmaceutical Research Reagents (for Experimental Use)Neurotransmitter Agent Ingredients (for Research and Experimental Use)
- Biochemicals and ReagentsPharmaceutical Research Reagents (for Experimental Use)Anti-Constipation Ingredients (for Research and Experimental Use)
- Biochemicals and Reagents
- Cell BiologyBioactive Small MoleculesReceptor Agonists
- Pharmaceutical Development and Drug Discovery ResearchPharmaceutical Research Reagents (for Experimental Use)Neurotransmitter Agent Ingredients (for Research and Experimental Use)
- Pharmaceutical Development and Drug Discovery ResearchPharmaceutical Research Reagents (for Experimental Use)Anti-Constipation Ingredients (for Research and Experimental Use)
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