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Description
Selexipag is a small molecule that acts as a selective agonist of the prostacyclin IP receptor, and it has become an important reference compound in vascular pharmacology research. Unlike lipid-based prostacyclin analogues, this compound is built on a non-prostanoid diphenylpyrazine framework that gives it a different chemical and stability profile. In the laboratory, the material is used as a research reagent in studies of vasodilation, G protein-coupled receptor signalling, and in experimental models of pulmonary hypertension and vascular remodelling, where a well-characterised IP receptor agonist is needed as a pharmacological tool.
The property that makes this compound a frequent choice is its selectivity for the IP receptor relative to other prostanoid receptor subtypes, which means that responses observed in an experiment can be attributed more confidently to a single signalling pathway. Activation of the IP receptor triggers an increase in cyclic AMP through adenylate cyclase, an output that can be measured quantitatively in cell-based assay systems. The compound is also known to be metabolised into its active form, making it an interesting example for studies of the relationship between structure, metabolism, and activity. As a small-molecule solid, it is more practical to handle than the naturally occurring prostanoids, which are highly labile.
In Indonesian laboratories, this material is typically used in academic and institutional research settings — university pharmacology and pharmacy departments, biomedical research centres, and laboratories working on cardiovascular and respiratory disease models. It is normally handled at research and experimental scale rather than in bulk, prepared as stock solutions for in vitro assays, and used alongside other reference agonists and antagonists so that receptor-specific responses can be compared within the same experimental series.
Laboratory Applications
- Vasodilation studies — the compound provides a defined IP receptor stimulus, so relaxation responses measured in vascular preparations can be linked to a specific receptor pathway rather than to mixed prostanoid effects.
- G protein-coupled receptor signalling research — IP receptor activation raises cyclic AMP through adenylate cyclase, giving a measurable second-messenger readout suitable for quantitative cell-based assay systems.
- Pulmonary hypertension model research — as a selective IP receptor agonist, it serves as a pharmacological tool for probing prostacyclin pathway involvement in experimental models of the disease.
- Vascular remodelling investigations — the compound allows researchers to examine how sustained IP receptor signalling influences vascular cell behaviour in controlled experimental systems over time.
- Structure–metabolism–activity studies — because it is converted into an active metabolite, it offers a useful teaching and research example of how chemical structure, metabolic transformation, and pharmacological activity are connected.
Specifications
- Brand: TCI
- Product code: E1613
- CAS number: 475086-01-2
- Category: Life Science > Biochemicals and Reagents > Pharmaceutical Ingredients (for Research and Experimental Use) [USP Drug Classification]
- Physical form: small-molecule solid
- Storage: store according to the conditions stated on the manufacturer's label and product documentation
Handling and Storage
Store the container in a cool, dry place away from direct sunlight, moisture, and sources of heat, following the storage conditions printed on the manufacturer's label. Keep the material in its original tightly closed container, or in a clean, well-sealed and clearly labelled vial if it is subdivided, to prevent contamination and moisture uptake. Handle the compound in a well-ventilated area or fume hood, and wear appropriate personal protective equipment including gloves, safety glasses, and a laboratory coat. Avoid generating dust when weighing the solid, minimise direct contact with skin and eyes, and follow standard laboratory procedures for the handling and disposal of research chemicals. This product is intended for research and experimental use only, and not for human or veterinary use.
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