Pembayaran hanya melalui request quotation dan dilakukan setelah tim kami menghubungi Anda. Mohon cantumkan nomor WhatsApp aktif untuk konfirmasi pesanan & pembuatan invoice. Estimasi pengiriman 4-5 minggu setelah pembayaran.
Couldn't load pickup availability
Description
TCI F0634 2-Fluoro-4-methoxyphenol is a substituted phenol carrying a fluorine atom at the ortho position and a methoxy group at the para position relative to the hydroxyl group. This three-substituent pattern makes it a rather distinctive fluorinated building block, because a single molecule already provides a nucleophilic phenol group, an electron-donating methoxy group, and a fluorine atom that modulates the electronic character of the aromatic ring. In the laboratory, a material of this kind saves a considerable number of synthetic steps, since the chemist does not need to install all three substituents one by one under complicated regiochemical control.
The characteristic that gives this compound its appeal lies in its balance of reactivity. The phenolic hydroxyl group is readily deprotonated by a weak base and then reacts with alkyl halides, acyl chlorides, or other electrophiles to form aryl ethers and esters. The fluorine atom at the ortho position lowers the pKa of the phenol compared with unsubstituted phenol, so deprotonation proceeds more easily, while the methoxy group at the para position keeps the ring electron-rich and reactive toward electrophilic substitution. The pair of oxygen-bearing groups on opposite positions of the ring also resembles substitution patterns frequently encountered in medicinal chemistry scaffolds.
In Indonesian laboratories, a fluorinated building block of this type is typically used in university research groups, pharmaceutical research units, and contract synthesis laboratories that prepare intermediates on a small scale. Researchers working on fluorine-containing target molecules generally purchase such starting materials in modest pack sizes, because the quantity needed per experiment is small while the demand for consistent, well-characterised material is high. It supports both exploratory route-scouting work and the preparation of reference compounds for analytical comparison.
Laboratory Applications
Fluorinated intermediate synthesis — the pre-installed fluorine atom removes the need for separate fluorination steps, which are often the most difficult and lowest-yielding operations in a multi-step route.
Aryl ether preparation — the phenolic hydroxyl is easily deprotonated with a weak base and then alkylated with alkyl halides, giving straightforward access to diaryl and alkyl aryl ether products.
Aryl ester formation — reaction of the deprotonated phenol with acyl chlorides or related electrophiles produces aryl esters cleanly, making the compound a convenient anchor point for acylation chemistry.
Medicinal chemistry scaffold construction — the arrangement of two oxygen-bearing substituents on opposite ring positions mirrors patterns commonly found in bioactive molecules, shortening scaffold assembly work.
Electrophilic aromatic substitution studies — the para-methoxy group keeps the ring electron-rich and reactive, so the compound serves well in investigations of substituent effects on ring reactivity.
Specifications
Brand: TCI (Tokyo Chemical Industry)
CAS number: 167683-93-4
Category: Chemistry > Building Blocks > Fluorinated Building Blocks
Product code: F0634
Pack sizes: available in standard research-scale laboratory pack sizes; please confirm the currently listed options when ordering
Storage: keep in a tightly closed container, protected from light and air, as is customary for substituted phenols
Handling and Storage
Store the container tightly closed in a cool, dry, and well-ventilated area, away from direct sunlight and sources of heat or ignition. Substituted phenols are generally sensitive to prolonged exposure to air and light, so the original supplier container should be kept sealed and reclosed promptly after each use; amber glass or the original packaging is preferable to clear containers. Handle the material inside a fume hood, wearing safety glasses, chemical-resistant gloves, and a laboratory coat, and avoid contact with skin and eyes as well as inhalation of any vapour or dust. Keep it separated from strong oxidising agents and strong bases. Always consult the manufacturer's safety data sheet before first use, and dispose of residues and contaminated materials through the laboratory's designated chemical waste stream.
