• Formic Acid [for LC-MS] (CAS 64-18-6) - TCI F0654 - AMI Scientific
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CAS 64-18-6

Formic Acid [for LC-MS] TCI F0654

Formic Acid [for LC-MS] TCI F0654
Rp 848.400,00
Rp 848.400,00
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TCI F0654 Formic Acid [for LC-MS] is a specialty-grade formic acid prepared for liquid chromatography coupled with mass spectrometry. Formic acid is the simplest carboxylic acid and has long served as a standard mobile phase additive in LC-MS analysis, used both in the aqueous phase and in organic solvents such as acetonitrile and methanol. Its role in the laboratory is to control mobile phase acidity so that analytes are protonated consistently, chromatographic peaks become symmetrical, and electrospray ionisation response improves. The LC-MS designation means this material is intended for work that is highly sensitive to background contamination.

The characteristic that makes formic acid the preferred additive is its volatility: it does not precipitate or accumulate in the ion source, unlike phosphate buffers or non-volatile salts, which instead foul the mass spectrometer interface. Formic acid also delivers adequate acidifying capacity at low concentration and is generally used at small levels in the mobile phase, so consumption is economical and elution strength is not altered drastically. The grade intended for LC-MS emphasises low background signal contribution, which is what separates it from ordinary reagent-grade formic acid in demanding detection work.

In Indonesian laboratories, this reagent belongs to routine LC-MS practice wherever trace-level detection is required and mobile phase quality directly determines the result. It is prepared into aqueous and organic mobile phases at the analyst's working concentration, then used across sample batches where reproducible retention time and stable ionisation response matter. Laboratories running method validation, repeated analytical runs, or instrument performance checks rely on a consistent additive grade so that variation observed in the data comes from the sample, not from the mobile phase.

  • Mobile phase acidification for LC-MS: added to aqueous and organic mobile phases to hold pH low, so target analytes stay consistently protonated and produce a stable, reproducible mass spectrometric response across an analytical run.
  • Electrospray ionisation enhancement in positive mode: the acidic environment promotes formation of protonated molecular ions, raising signal intensity for compounds that ionise poorly in unmodified mobile phase conditions during trace analysis.
  • Chromatographic peak shape improvement: consistent acidification suppresses unwanted ionic interactions during separation, so peaks elute symmetrically rather than tailing, which makes integration and quantitation far more reliable.
  • Trace-level analytical work sensitive to background: the LC-MS grade is specified for low background signal contribution, making it suitable for methods where contaminant peaks would otherwise obscure genuine low-concentration analytes.
  • Reversed-phase LC-MS method development and validation: a volatile additive that will not deposit in the ion source lets analysts optimise gradients and test conditions without progressively contaminating the mass spectrometer interface.

Brand TCI
CAS number 64-18-6
Molecular formula —
Purity —
Category Analytical Chemistry > Analytical Reagents > Chromatography Reagents and Solvents
Pack sizes please refer to the catalogue listing for currently offered pack sizes
Physical form —
Storage keep tightly closed in a cool, well-ventilated area away from incompatible materials
  • Catalogue number: F0654
  • Grade: specialty grade for LC-MS, emphasising low background signal contribution

Store the container tightly closed in a cool, dry, well-ventilated area, away from heat, ignition sources, and incompatible materials such as strong bases and oxidising agents. Keep the reagent in its original supplier container or in a compatible, chemically resistant vessel that seals properly, since exposure to air and moisture can compromise the low-background quality required for LC-MS work. Formic acid is corrosive and its vapour is irritating, so all handling, dilution, and mobile phase preparation should be carried out in a fume hood while wearing safety glasses, chemical-resistant gloves, and a laboratory coat. Dispense only the volume needed for immediate use and reclose the container promptly to avoid contamination that would appear as background signal. Consult the manufacturer's safety data sheet before use, and follow local institutional rules for chemical waste disposal.

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