TCI
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Description
Fludarabine is a chemical compound classified under nucleosides and widely used in biochemical and pharmacological research. It is a key reagent in laboratories where DNA and RNA synthesis, transcription, and genetic modification experiments are conducted. Due to its molecular structure, which closely resembles DNA and RNA nucleotides, it plays a crucial role in various experimental setups. This compound is particularly valuable in studies related to the mechanisms of antitumor drugs, especially in the treatment of leukemia and lymphoma. Its versatility makes it an essential component in both basic and clinical research settings.
Fludarabine is chemically stable under specific conditions but is highly sensitive to moisture and oxidation. The presence of a phosphate group in its structure allows it to interact with enzymes such as kinases, making it a preferred choice for biochemical studies. Its ability to participate in enzymatic reactions and its compatibility with various experimental protocols make it a reliable reagent for researchers. The compound’s predictable behavior and consistent performance contribute to its popularity in laboratory environments.
In Indonesian laboratories, Fludarabine is commonly used in clinical and fundamental research within the fields of pharmacology and biochemistry. It is an essential material for educational institutions and research organizations that focus on drug development and molecular biology. Its application in both academic and applied research underscores its importance in advancing scientific knowledge and innovation.
Laboratory Applications
- Antitumor Drug Mechanism Studies: Fludarabine is used to investigate how chemotherapy drugs interact with cancer cells, particularly in leukemia and lymphoma research.
- DNA and RNA Synthesis Experiments: Its molecular similarity to nucleotides makes it ideal for experiments involving DNA and RNA synthesis and modification.
- Enzymatic Reaction Testing: The phosphate group in Fludarabine enables it to interact with kinases, making it suitable for enzyme activity assays and biochemical pathway studies.
- Genetic Modification Research: It is used in experiments that require the manipulation of genetic material, such as gene editing and transcription studies.
- Pharmacological Research: Fludarabine supports studies on drug efficacy and toxicity, contributing to the development of new therapeutic agents.
Specifications
- Brand: TCI
- CAS number: 21679-14-1
- Category: Life Science > Biochemicals and Reagents > Nucleosides, Nucleotides, Oligonucleotides
- Pack sizes: Available in various quantities as per standard laboratory reagent packaging
- Physical form: Solid powder
- Storage note: Store in a cool, dry place away from moisture and light
Handling and Storage
Fludarabine should be stored in a cool, dry environment to maintain its chemical stability. It is recommended to keep it in airtight containers to prevent exposure to moisture and oxidation, which can degrade its properties. Laboratory personnel should handle the compound with care, using appropriate personal protective equipment such as gloves and safety goggles. Due to its sensitivity, it is important to avoid contact with water and to store it in a location that is inaccessible to direct sunlight. Proper labeling of containers is essential to ensure safe handling and prevent accidental contamination. Regular monitoring of storage conditions helps maintain the integrity of the compound for reliable experimental results.
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