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Description
TCI F0660 2-Fluoro-6-iodobenzonitrile is an aromatic building block that carries three functional groups on a single benzene ring at once: a nitrile, a fluorine, and an iodine. This combination makes it a highly versatile starting material in organic synthesis, because each group can be directed toward a different transformation. In the laboratory, a compound of this kind serves as a starting point for constructing complex molecules step by step, ranging from cross-coupling reactions at the iodine position through to conversion of the nitrile group into an amide, a carboxylic acid, an amine, or a heterocyclic ring.
The characteristic that makes this material a preferred choice is the ordered reactivity of its three functional groups. The iodine atom is the most reactive leaving group among the aromatic halogens in palladium-catalysed coupling reactions, so that position can be modified first without disturbing the fluorine atom. The nitrile group is electron-withdrawing and activates the ring toward nucleophilic aromatic substitution, opening a second, controllable reaction pathway. The fluorine atom, meanwhile, contributes high bond stability and influences the polarity of the product. The ortho arrangement between the three substituents is also useful for building fused ring frameworks.
In Indonesian laboratories, a building block of this type is typically used in university research groups, in pharmaceutical and agrochemical development work, and in method development for multi-step synthesis. It is usually ordered in small research-scale quantities for route scouting and reaction optimisation before a synthesis is scaled up. Because it is supplied as a catalogue chemical from TCI, it fits the workflow of laboratories that require consistent, well-defined starting materials for reproducible experimental work.
Laboratory Applications
- Palladium-catalysed cross-coupling chemistry: the aryl iodide position reacts selectively under standard coupling conditions, allowing new carbon-carbon bonds to be formed while the fluorine substituent remains untouched.
- Nucleophilic aromatic substitution studies: the electron-withdrawing nitrile group activates the ring toward attack by nucleophiles, giving researchers a controllable second handle for selective functionalisation of the aromatic core.
- Heterocycle construction: the nitrile group can be cyclised or condensed to build nitrogen-containing rings, making this compound a practical entry point into fused heterocyclic scaffolds for discovery chemistry.
- Fluorinated intermediate preparation: the carbon-fluorine bond is retained through many synthetic steps, so this building block is used to introduce fluorine early into pharmaceutical and agrochemical candidate structures.
- Multi-step route development: the differing reactivity of the iodine, nitrile, and fluorine groups lets chemists design sequential, orthogonal transformations when planning and optimising complex synthetic routes.
Specifications
- Brand: TCI (Tokyo Chemical Industry)
- CAS number: 79544-29-9
- Chemical name: 2-Fluoro-6-iodobenzonitrile
- Catalogue code: F0660
- Category: Chemistry > Building Blocks > Fluorinated Building Blocks
- Pack sizes: available in standard TCI research-scale catalogue pack sizes; please confirm the currently listed options when ordering
- Storage: store in a tightly closed container in a cool, dry, well-ventilated place, protected from light
Handling and Storage
Store the container tightly closed in a cool, dry, and well-ventilated area, away from direct sunlight, heat sources, and incompatible materials such as strong oxidising agents and strong bases. Keep the material in its original supplier container, or transfer it only to a clean, chemically compatible, tightly sealed amber glass container that is clearly labelled with the compound name, CAS number, and date of receipt or opening. Handle the compound inside a fume hood using appropriate personal protective equipment, including safety goggles, chemical-resistant gloves, and a laboratory coat. Minimise the generation of dust and avoid contact with skin, eyes, and clothing. Weigh out only the quantity required for immediate use, reseal the container promptly to limit exposure to moisture and air, and dispose of residues and contaminated materials as chemical waste in accordance with institutional and local regulations. Always consult the manufacturer's safety data sheet before use.
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