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Description
TCI F0663 Flutamide (CAS 13311-84-7) is a fluorinated nonsteroidal compound widely recognised as an androgen receptor antagonist, supplied here as a reagent intended for research purposes. Its structure carries a nitro group, a trifluoromethyl group, and an amide group on an aromatic framework, making it chemically distinct from steroid-type antiandrogenic compounds. In the laboratory, this compound serves as a tool for tracing androgen hormone signalling pathways, as a comparative control in cell-based biological assays, and as a reference material in the development and validation of analytical methods.
The characteristics that lead researchers to select this compound centre on its selectivity in binding the androgen receptor without possessing a steroid skeleton, so that side effects arising from interaction with other hormone receptors can be relatively well separated within an experimental design. The trifluoromethyl group increases the lipophilicity of the molecule and its resistance to metabolic breakdown, while the nitro group imparts a strong electron-withdrawing character to the aromatic ring. Supplied as a pure solid, the material is easily weighed in milligram quantities and dissolved in organic solvents such as dimethyl sulfoxide to prepare stable stock solutions.
In Indonesian laboratories, this reagent is typically used in university pharmacology and biochemistry research groups, in molecular biology and cell culture facilities, and in analytical laboratories that require a well-defined reference substance. Because milligram-scale weighing and dissolution in an organic solvent such as dimethyl sulfoxide are sufficient to prepare working stocks, the material fits routine bench workflows in academic and institutional research settings where the compound is handled strictly for experimental use.
Laboratory Applications
Androgen signalling pathway studies: the compound acts as a receptor antagonist tool, allowing researchers to trace how androgen hormone signalling is transmitted and where it can be interrupted.
Cell-based biological assays: it serves as a comparative control substance, giving a chemically defined reference point against which experimental treatments in cultured cell systems can be judged.
Analytical method development and validation: as a reference material with a defined structure, it supports the establishment and verification of analytical procedures that must detect this class of compound.
Receptor selectivity investigations: because it binds the androgen receptor without a steroid skeleton, interactions with other hormone receptors can be relatively separated within a carefully planned experimental design.
Structure-activity studies on fluorinated compounds: the trifluoromethyl and nitro substituents provide a clear model for examining lipophilicity, metabolic resistance, and electron-withdrawing effects on an aromatic ring.
Specifications
Brand: TCI
CAS number: 13311-84-7
Category: Life Science > Biochemicals and Reagents > Pharmaceutical Research Reagents (for Experimental Use)
Pack sizes: available in standard TCI catalogue pack sizes; please confirm the required size when ordering
Physical form: pure solid, readily weighed in milligram quantities and dissolved in organic solvents such as dimethyl sulfoxide
Storage note: keep the container tightly closed and store according to the manufacturer's stated conditions on the product label
Handling and Storage
Store the compound in its original tightly closed container, protected from moisture and direct light, and follow the storage conditions stated by the manufacturer on the product label. Use clean, dry glass or chemically compatible plastic containers for any prepared stock solutions, and label them clearly with the compound name, solvent, and preparation date. Weigh the solid inside a fume hood or a suitable enclosure to avoid inhaling airborne particles, and wear gloves, a laboratory coat, and eye protection throughout handling. This material is intended for experimental use only and must not be used for human or veterinary purposes. Dispose of residues and contaminated consumables through the laboratory's designated chemical waste stream.
