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Description
Fenofibrate is a fibric acid derivative compound widely recognised in lipid metabolism research. In a laboratory context, this material is classified as a pharmaceutical research reagent for experimental use, not as a preparation intended for human therapeutic purposes. Its primary role in the laboratory is as a test compound and reference material in studies of nuclear receptor signalling pathways, particularly PPAR alpha, because fenofibrate is an ester form that is hydrolysed within biological systems into fenofibric acid, the species that is active toward that receptor.
The property that makes this material a frequent choice among researchers is its role as a model lipophilic compound with low aqueous solubility. This characteristic makes it an extremely popular reference substance in formulation technology research, spanning the development of solid dispersions, nanosuspensions, lipid-based carrier systems, and cyclodextrin complexes, because every improvement in solubility can be measured clearly through dissolution testing. On the molecular biology side, fenofibrate is used to examine the regulation of genes related to fatty acid oxidation, lipoprotein transport, and inflammatory responses in cell culture, with its clearly defined ester structure supporting reproducible experimental design.
In Indonesian laboratories, this reagent is typically handled within university pharmacy and pharmaceutical technology research groups, biochemistry and molecular biology laboratories, and formulation development units that require a well-characterised poorly water-soluble model compound. It is used strictly on an experimental scale, under documented protocols, by personnel trained in the handling of pharmaceutical research reagents, and it is not intended for clinical, diagnostic, or human therapeutic application of any kind.
Laboratory Applications
- PPAR alpha signalling studies — serves as a reference test compound whose ester form is hydrolysed biologically into the receptor-active fenofibric acid, allowing pathway activation to be examined systematically.
- Solubility enhancement and formulation research — its low aqueous solubility makes it a benchmark model compound for developing solid dispersions, nanosuspensions, and other solubility-improving formulation strategies.
- Lipid-based carrier system development — the lipophilic character of this material suits it to studies on lipid carriers, where partitioning behaviour and carrier loading can be evaluated meaningfully.
- Cyclodextrin complexation experiments — the compound is widely used as a guest molecule in inclusion complex research because resulting solubility gains are readily quantified by dissolution testing.
- Gene regulation studies in cell culture — applied to examine expression related to fatty acid oxidation, lipoprotein transport, and inflammatory responses under controlled experimental conditions.
Specifications
- Brand: TCI
- Catalogue number: F0674
- CAS number: 49562-28-9
- Category: Life Science > Biochemicals and Reagents > Pharmaceutical Research Reagents (for Experimental Use)
- Pack sizes: available in standard research pack sizes as listed by the manufacturer
- Storage note: store according to the manufacturer's stated conditions on the product label and certificate of analysis
Handling and Storage
Store this reagent in its original tightly closed container, protected from moisture, direct sunlight, and sources of heat, and follow the storage temperature stated by the manufacturer on the product label. Amber glass or the supplied original packaging is suitable for keeping the material away from light. Handle in a well-ventilated area or a fume hood, wearing a laboratory coat, gloves, and safety glasses, and avoid generating dust when weighing the solid. Keep the container closed when not in use, record each withdrawal, and consult the safety data sheet before first handling. Dispose of residues and contaminated materials in accordance with applicable laboratory chemical waste procedures, and restrict handling to personnel trained in the use of pharmaceutical research reagents for experimental purposes only.
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