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Description
TCI F0681 4-Fluoro-3-methoxybenzoic Acid is a fluorinated aromatic compound positioned as a starting material, or building block, for laboratory-scale organic synthesis work. Its molecular framework consists of a benzene ring carrying three functional groups at once: a carboxylic acid that serves as the principal reaction site, a fluorine atom, and a methoxy group, all arranged at adjacent positions on the ring. This arrangement means the material can be used directly as a core scaffold when researchers assemble larger target molecules, saving several synthetic steps that would otherwise have to be carried out in-house starting from a simpler parent compound.
The characteristic that makes this compound a frequent choice is the combination of a carboxylic acid group that is very readily converted into amides, esters, acid chlorides, or alcohols, together with the presence of a fluorine atom that exerts a strong electronic influence on the aromatic ring. The fluorine atom, positioned para to the methoxy group, alters the distribution of electron density across the ring, affecting the reactivity of the ring toward both nucleophilic and electrophilic attack, while also serving as a structural feature frequently sought in the design of bioactive molecules. The methoxy group contributes further electronic and steric character to the same framework.
In Indonesian laboratories, this building block is typically drawn on by university research groups, pharmaceutical and agrochemical R&D teams, and analytical or method-development laboratories that need a ready-made fluorinated aromatic scaffold. It is generally purchased in laboratory-scale quantities for multi-step synthesis routes, for the preparation of derivative libraries, and for exploratory work where obtaining the substituted ring pattern from simpler precursors would consume time and reagents better spent on the later stages of the route.
Laboratory Applications
- Organic synthesis scaffold construction: the pre-installed fluorine and methoxy substituent pattern lets researchers begin a multi-step route several stages further along than a simple benzoic acid starting material would allow.
- Amide and ester derivative preparation: the carboxylic acid group is readily activated and coupled, making this compound a convenient handle for generating families of amide, ester, and acid chloride derivatives.
- Medicinal chemistry and bioactive molecule design: fluorine substitution on an aromatic ring is a structural motif frequently pursued in drug discovery programmes, and this building block supplies that motif directly.
- Derivative library generation: because a single reactive site dominates the molecule, parallel reactions on the carboxylic acid produce structurally related compound sets for screening from one common intermediate.
- Reactivity and structure–activity studies: the combined electronic effects of the fluorine and methoxy groups make this compound a useful substrate for investigating how substitution patterns govern aromatic ring reactivity.
Specifications
- Brand: TCI (Tokyo Chemical Industry)
- CAS number: 82846-18-2
- Category: Chemistry > Building Blocks > Fluorinated Building Blocks
- Product code: F0681
- Pack sizes: available in standard TCI laboratory research pack sizes; please confirm the required quantity when ordering
- Storage: store in a tightly closed container in a cool, dry, well-ventilated area as indicated on the product label and safety data sheet
Handling and Storage
Store the material in its original tightly closed container in a cool, dry, and well-ventilated place, away from direct sunlight, moisture, and incompatible substances. Keep the container sealed when not in use to prevent moisture uptake and contamination of the contents. Handle the compound in a fume hood using appropriate personal protective equipment, including safety goggles, chemical-resistant gloves, and a laboratory coat, and avoid the generation and inhalation of dust during weighing and transfer. Use clean, dry spatulas and glassware to preserve sample integrity, and always consult the manufacturer's safety data sheet for the full hazard classification, first-aid measures, and disposal requirements before beginning work.
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