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Description
TCI F0798 2-Fluoro-4-nitroaniline is a fluorinated aniline that carries a nitro group at the para position relative to the amine group, with a fluorine atom occupying the ortho position. The compound is a classic intermediate in organic synthesis and in the dyestuff industry, and it is also widely used as a nitrogen heterocycle precursor in research laboratories. The presence of a free amine group allows acylation, sulfonylation, alkylation, and diazotization reactions, while the nitro group provides a route toward a second amine through controlled reduction that is easily carried out with common laboratory reagents.
Its advantage lies in a substitution pattern that gives reasonably clear reaction direction. The electron-withdrawing para nitro group lowers the basicity of the amine group and stabilizes the diazonium salt that is formed, which makes this compound a reliable diazo component in the preparation of azo dyes. The ortho fluorine atom contributes additional electronic and steric influence that is often exploited to tune the physicochemical properties of the final product, including solubility and stability. The material is generally a yellow crystalline solid that is easy to weigh out and stable under correct storage.
In Indonesian laboratories, this compound is typically found in organic synthesis and medicinal chemistry research groups at universities, in textile and dye-related research units, and in industrial development laboratories that build fluorinated intermediates. It is normally handled on a small preparative scale, weighed directly as a solid, and used in multi-step sequences where the amine and nitro functions are transformed in turn. Supplied under the TCI brand, it fits routine bench work in academic and industrial settings alike.
Laboratory Applications
Azo dye synthesis: the amine group can be diazotized and the resulting diazonium salt is stabilized by the para nitro group, making the compound a dependable diazo component for coupling reactions.
Nitrogen heterocycle preparation: the adjacent amine and activated aromatic ring provide a convenient entry point for building nitrogen-containing heterocyclic scaffolds frequently required in research-scale organic synthesis.
Controlled reduction to diamines: the nitro group can be reduced with common laboratory reagents to generate a second amine, giving access to substituted fluorinated phenylenediamine intermediates for further derivatization work.
Amine derivatization studies: the free amine readily undergoes acylation, sulfonylation, and alkylation, so the compound serves well as a model substrate when optimizing reaction conditions and protecting group strategies.
Fluorinated building block research: the ortho fluorine atom supplies electronic and steric effects used to tune solubility and stability of final products, supporting medicinal and materials chemistry development programs.
Specifications
Brand: TCI
CAS number: 369-35-7
Category: Chemistry > Building Blocks > Fluorinated Building Blocks
Pack sizes: available in standard laboratory research pack sizes; please confirm the required size when ordering
Physical form: yellow crystalline solid
Storage: store under the correct conditions described below to maintain stability
Handling and Storage
Store the material in a tightly closed original container, kept in a cool, dry, and well-ventilated area away from direct sunlight, heat sources, and incompatible reagents. Amber glass or the supplier's own packaging is suitable, and the container should be resealed promptly after each weighing to limit moisture uptake and contamination. Handle the solid inside a fume hood, using gloves, safety glasses, and a laboratory coat, and avoid generating or inhaling dust during transfer. As a nitroaromatic amine, it should be treated with care, and all waste and contaminated materials should be collected separately for disposal according to institutional chemical waste procedures. Always consult the current safety data sheet before use.
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