Potassium Guaiacolsulfonate TCI G0160

Chemical Identity

Other names: Guaiacolsulfonic Acid Potassium Salt · 4-Hydroxy-3-methoxybenzenesulfonic Acid Potassium Salt · Potassium 4-Hydroxy-3-methoxybenzenesulfonate
CAS No.: 16241-25-1
PubChem: CID 23679005·SID 87570355
Formula: C7H7KO5S
Molecular weight: 242.29 g/mol
Purity: >98.0%(HPLC)(T)
Reference databases: ChEBI·ChemSpider

Full identifiers (IUPAC, SMILES, InChIKey)

IUPAC: potassium 4-hydroxy-3-methoxybenzenesulfonate
SMILES: COC1=C(C=CC(=C1)S(=O)(=O)[O-])O.[K+]
InChIKey: QFRKWSPTCBGLSU-UHFFFAOYSA-M
MDL: MDL00053298

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TCI G0160 Potassium Guaiacolsulfonate is the potassium salt of guaiacolsulfonic acid. It is a derivative of guaiacol (2-methoxyphenol) with a sulfonate group on its aromatic ring. The compound is widely known as the active expectorant ingredient in cough medicine preparations. In the laboratory it is classified as a non-heterocyclic building block. Its main roles are as a reference material for pharmaceutical analysis, as a material for formulation research, and as a precursor in studies on the chemistry of sulfonated phenol derivatives.

Potassium guaiacolsulfonate is often chosen because its phenol, methoxy and sulfonate groups together make it readily soluble in water. This makes it easy to use in aqueous systems such as syrups, test solutions and chromatographic mobile phases. Because it is a salt, the material is relatively stable and easier to weigh than the free sulfonic acid. Its substituted aromatic ring gives a characteristic ultraviolet absorption, so the compound can be detected by UV spectrophotometry or by HPLC with UV detection. Many laboratories already have these methods available.

For Indonesian laboratories, this material is most useful in the pharmaceutical industry, in quality control laboratories and in pharmacy study programmes. Pharmaceutical manufacturers and quality control teams can use it to support identity checks and assays of cough syrup formulations. University pharmacy departments can use it to teach pharmaceutical analysis, run UV and HPLC practicals, and support student research on formulation. Research groups studying phenolic compounds can also use it as a well-defined starting material for exploring the chemistry of sulfonated aromatic derivatives.

TCI brochures (PDF)

Pharmaceutical Ingredients for Research and Experimental Use 2026-03-09 · p. 45

Related TCI products

Pharmaceutical reference analysis: as a reference material in assays of expectorant preparations, where its distinctive UV absorption supports reliable identification and quantification by HPLC with UV detection.
Cough syrup formulation research: its good water solubility allows straightforward incorporation into aqueous syrup systems, so researchers can study formulation behaviour, compatibility and dosage form development.
Quality control testing: quality control laboratories can prepare aqueous test solutions with it to check the identity and content of finished products, using UV spectrophotometry or HPLC methods they already have.
Chemistry of sulfonated phenol derivatives: as a precursor and model compound, its combination of phenol, methoxy and sulfonate groups on one aromatic ring makes it a useful non-heterocyclic building block for studying this class of compounds.
Teaching pharmaceutical analysis: pharmacy study programmes can use it in practical classes because it dissolves easily in water, weighs conveniently as a salt and is detectable with common UV-based instruments.

Brand	TCI (product code G0160)
CAS number	16241-25-1
Molecular formula	—
Purity	—
Category	Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
Pack sizes	available in TCI standard pack sizes; please confirm the available options when ordering
Physical form	potassium salt, relatively stable and easy to weigh
Storage	keep the container tightly closed in a cool, dry place and follow the manufacturer's label and Safety Data Sheet

Store Potassium Guaiacolsulfonate in its original, tightly closed container in a cool, dry, well-ventilated area, away from direct sunlight, heat sources and incompatible substances such as strong oxidising agents. Because the material is readily soluble in water, protect it from moisture by closing the container right after each use. If you transfer it to another container, use a clean, dry, chemically compatible one with clear labelling. Wear standard laboratory protective equipment, including a lab coat, safety glasses and gloves. Avoid creating dust, and weigh the material in a well-ventilated area or under local exhaust. Wash your hands after handling it. Always check the TCI Safety Data Sheet for specific hazard, first-aid and disposal information before use.

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