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Description
Potassium Guaiacolsulfonate is the potassium salt of guaiacolsulfonic acid, a guaiacol derivative carrying a sulfonate group on its aromatic ring. The addition of the strongly polar sulfonate group transforms guaiacol — originally an oily substance with a sharp odour — into a stable salt in solid form that dissolves readily in water. In the laboratory, this compound is used as a raw material for pharmaceutical research, as a reference standard in the analysis of combination cough preparations, and as a study material in organic chemistry concerning sulfonation reactions of methoxylated phenolic compounds.
The characteristics that make this compound a preferred choice are its high solubility in water, which allows standard solutions to be prepared without organic solvents, and its stability as a solid salt, which simplifies weighing and long-term storage. The aromatic ring bearing methoxy and hydroxy groups gives clear ultraviolet absorption, so detection by HPLC with a UV detector or by spectrophotometer proceeds sensitively and consistently. Its ionic nature also makes it an interesting analyte in the development of ion-pair chromatography methods as well as reversed-phase chromatography with appropriate pH control.
In Indonesian laboratories, this material is typically encountered in pharmaceutical industry quality control settings, where combination cough preparations are routinely assayed and a reliable comparison standard is required. It is equally at home in academic and research laboratories studying phenolic chemistry and sulfonation, and in analytical method development groups building and validating chromatographic procedures. Its water solubility suits laboratories that prefer to minimise organic solvent handling in routine standard preparation.
Laboratory Applications
Pharmaceutical research raw material: supplied as a defined guaiacol derivative, it serves as a starting material for synthetic and formulation studies on methoxylated phenolic compounds.
Reference standard for combination cough preparation assays: its stable solid salt form and consistent ultraviolet absorption allow reproducible comparison standards for routine pharmaceutical quality control testing.
HPLC method development with UV detection: the methoxy- and hydroxy-substituted aromatic ring provides clear ultraviolet absorption, giving sensitive and consistent chromatographic detection across runs.
Ion-pair chromatography studies: the ionic sulfonate group makes this compound an attractive model analyte for developing and optimising ion-pair separation methods in analytical laboratories.
Organic chemistry teaching and research on sulfonation: it illustrates how introducing a polar sulfonate group onto a phenolic ring changes physical state, odour and solubility behaviour.
Specifications
Brand: TCI
CAS number: 16241-25-1
Category: Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
Pack sizes: available in the standard TCI catalogue pack sizes for this product code (G0160)
Physical form: solid salt, readily soluble in water
Storage: keep in a tightly closed container, protected from moisture, in accordance with the manufacturer's label
Handling and Storage
Store the container tightly closed in a cool, dry place away from direct sunlight, and follow any storage instruction printed on the manufacturer's label. Because the material is a water-soluble salt, protection from moisture is important to preserve free-flowing solid and accurate weighing. Use clean, dry spatulas and glassware, and reseal the container promptly after dispensing to limit exposure to humid air. Handle in a well-ventilated area or fume hood, wear a laboratory coat, safety goggles and suitable gloves, and avoid generating or inhaling dust. Consult the supplier's safety data sheet before use, and dispose of residues and contaminated materials according to applicable laboratory waste procedures.
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