TCI
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Description
TCI G0184 Diethyl Glutarate is the diethyl ester of glutaric acid, supplied as a clear, colourless liquid with a mild ester odour. Its molecule carries two ester groups separated by a three-carbon chain, an arrangement that makes it a versatile building block in organic chemistry. In the laboratory, the material serves as an intermediate for constructing medium-sized carbon skeletons, as a reaction partner in ester condensations, and as a starting material for the preparation of polyesters and cyclic compounds. Its liquid form makes transfer by pipette or syringe straightforward, with no need to weigh out a solid.
The properties that make this material a frequent choice are the symmetry of its molecule and the spacing between the two ester groups, which is well suited to ring closure. Under Dieckmann condensation conditions with a strong base, the diester closes to form a five-membered ring, the classic entry point to cyclopentanone derivatives. Both ester groups are also readily reduced to the corresponding diol or hydrolysed back to the dicarboxylic acid, giving researchers a wide choice of transformation pathways. In addition, dibasic esters of this kind evaporate slowly and dissolve many resins well.
In Indonesian laboratories, this reagent is typically found in synthetic organic chemistry groups at universities and research institutes, in polymer laboratories preparing polyester samples, and in industrial development units working on intermediates. Because it is handled as a liquid, it fits routine bench workflows where reagents are drawn by syringe into reaction flasks. It is usually kept alongside other building-block esters in a general chemical store, ready for use in multi-step synthesis routes.
Laboratory Applications
- Dieckmann condensation to cyclopentanone derivatives: the three-carbon spacing between the two ester groups allows intramolecular closure into a stable five-membered ring under strong base.
- Preparation of polyesters: the two reactive ester groups let the molecule act as a difunctional monomer that can be linked repeatedly into an extended polymer backbone.
- Synthesis of medium-sized carbon skeletons: the compound provides a symmetrical five-carbon frame that can be elaborated at either end without confusing regiochemistry during the build-up.
- Reduction to diols: both ester groups can be reduced in a single operation, giving a convenient route to a symmetrical difunctional alcohol for further coupling work.
- Solvent or carrier for resin work: as a dibasic ester it evaporates slowly and dissolves many resins, which suits formulation trials and controlled-evaporation applications on the bench.
Specifications
- Brand: TCI
- CAS number: 818-38-2
- Category: Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
- Pack sizes: available in the standard TCI catalogue pack sizes; please confirm the size required when ordering
- Physical form: clear, colourless liquid with a mild ester odour
- Storage: keep in a tightly closed container in a cool, dry, well-ventilated place
Handling and Storage
Store the container tightly closed in a cool, dry and well-ventilated area, away from heat sources, open flames and direct sunlight, and separated from strong bases, strong acids and strong oxidising agents. Original manufacturer bottles or compatible glass containers with well-sealing caps are suitable; avoid containers whose liners may be attacked by esters. Handle and transfer the liquid in a fume hood, wearing safety goggles, chemical-resistant gloves and a laboratory coat. Use a pipette or syringe for dosing to limit vapour release, keep the bottle closed when not in use, and clean up any spill promptly with an inert absorbent. Always consult the manufacturer's safety data sheet before first use.
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